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  1. Content type: Research

    The underlying pathology and natural course of Modic changes (MC) in the vertebral body marrow and high intensity zones (HIZs) in the annulus fibrosus is not completely clarified. These findings on magnetic re...

    Authors: Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg and Ansgar Espeland

    Citation: Journal of Negative Results in BioMedicine 2012 11:13

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  2. Content type: Research

    The overstimulation of excitatory glutamatergic neurotransmission and the inhibition of Na+,K+-ATPase enzymatic activity have both been implicated in neurotoxicity and are possibly related to the pathogenesis of ...

    Authors: Marcos Brandão Contó and Marco Antonio Campana Venditti

    Citation: Journal of Negative Results in BioMedicine 2012 11:12

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  3. Content type: Research

    Fetal conditions are known to be partly responsible for the child’s risk for obesity. Our pilot study aimed to determine the effect of gestational lifestyle counseling on the offspring weight gain until 4 year...

    Authors: Taina Mustila, Jani Raitanen, Päivi Keskinen, Antti Saari and Riitta Luoto

    Citation: Journal of Negative Results in BioMedicine 2012 11:11

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  4. Content type: Research

    Periodontal disease is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss in severe clinical cases. Interleukin (IL)-6, IL-8, and the chemical medi...

    Authors: Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori and Hiroo Miyazawa

    Citation: Journal of Negative Results in BioMedicine 2012 11:10

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  5. Content type: Research

    Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 (FBN1) gene, and mutations in FBN1 are known to be responsible for over 90% of all MFS cases. Locus heterogeneity has also been reported and confirm...

    Authors: Krishna K Singh, Joerg Schmidtke, Britta Keyser and Mine Arslan-Kirchner

    Citation: Journal of Negative Results in BioMedicine 2012 11:9

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  6. Content type: Brief report

    Metallothioneins (MTs) are excellent candidate genes for Inflammatory Bowel Disease (IBD) and have previously been shown to have altered expression in both animal and human studies of IBD. This is the first st...

    Authors: Angharad R Morgan, Alan G Fraser and Lynnette R Ferguson

    Citation: Journal of Negative Results in BioMedicine 2012 11:8

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  7. Content type: Research

    Crohn's disease (CD) and ulcerative colitis (UC), the two main types of inflammatory bowel disease (IBD), are multifactorial conditions of unknown etiology. The objective of this study is to examine the combin...

    Authors: Ziad M Kanaan, Maurice R Eichenberger, Surriya Ahmad, Clayton Weller, Henry Roberts, Jianmin Pan, Shesh N Rai, Robert Petras, E Brooks Weller Jr and Susan Galandiuk

    Citation: Journal of Negative Results in BioMedicine 2012 11:7

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  8. Content type: Research

    Loss of basal forebrain cholinergic neurons is attributable to the proapoptotic signaling induced by nerve growth factor receptor (NGFR) and may link to Alzheimer's disease (AD) risk. Only one study has invest...

    Authors: Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen and Yen-Ching Chen

    Citation: Journal of Negative Results in BioMedicine 2012 11:5

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  9. Content type: Research

    Except for the I/D polymorphism in the angiotensin I-converting enzyme (ACE) gene, there were few reports about the relationship between other genetic polymorphisms in this gene and the changes in cardiac stru...

    Authors: Yongwoo Jang and Sung Min Kim

    Citation: Journal of Negative Results in BioMedicine 2012 11:6

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  10. Content type: Research

    Calstabins 1 and 2 bind to Ryanodine receptors regulating muscle excitation-contraction coupling. Mutations in Ryanodine receptors affecting their interaction with calstabins lead to different cardiac patholog...

    Authors: Diogo G Biagi, José G Mill, Alfredo J Mansur, José E Krieger and Alexandre C Pereira

    Citation: Journal of Negative Results in BioMedicine 2012 11:4

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  11. Content type: Research

    Adipose tissue is a source of multipotent adult stem cells and it has the ability to differentiate into several types of cell lineages such as neuron cells, osteogenic cells and adipogenic cells. Several repor...

    Authors: Wan Kamarul Zaman Wan Safwani, Suzana Makpol, Somasundaram Sathapan and Kien Hui Chua

    Citation: Journal of Negative Results in BioMedicine 2012 11:3

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  12. Content type: Research

    Loss of normal cell cycle control is an early event in the evolution of cancer. The expression of cyclin-dependent kinase (CDK) inhibitors p16 and p27 has been previously associated with progression of prostat...

    Authors: Panagiotis J Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, Kassiani Kapatou, Ioannis Gioulbasanis, Danai D Daliani, George Moutzouris and Christos N Papandreou

    Citation: Journal of Negative Results in BioMedicine 2012 11:2

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  13. Content type: Research

    The time of ovulation has since long been believed to be concealed to male heterosexual partners. Recent studies have, however, called for revision of this notion. For example, male testosterone concentrations...

    Authors: Jakob O Strom, Edvin Ingberg, Emma Druvefors, Annette Theodorsson and Elvar Theodorsson

    Citation: Journal of Negative Results in BioMedicine 2012 11:1

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  14. Content type: Research

    This work describes the experience at a tuberculosis clinical laboratory where relatively new TB diagnosis technologies; nucleic acid detection of two target strands, IS6110 and devR, by PCR and microscopic obser...

    Authors: Anita Mashta, Pooja Mishra, Sonia Philipose, S Tamilzhalagan, Hanif Mahmud, Sangeeta Bhaskar and Pramod Upadhyay

    Citation: Journal of Negative Results in BioMedicine 2011 10:16

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  15. Content type: Brief report

    The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymor...

    Authors: Raquel M Scarel-Caminaga, Karen MC Curtis, Rivelto Renzi, Patrícia M Sogumo, Giovana Anovazzi, Aline C Viana, Yeon J Kim, Silvana RP Orrico and Joni A Cirelli

    Citation: Journal of Negative Results in BioMedicine 2011 10:14

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  16. Content type: Research

    The gene family KCNE1-5, which encode modulating β-subunits of several repolarising K+-ion channels, has been associated with genetic cardiac diseases such as long QT syndrome, atrial fibrillation and Brugada syn...

    Authors: Paula L Hedley, Ole Haundrup, Paal S Andersen, Frederik H Aidt, Morten Jensen, Johanna C Moolman-Smook, Henning Bundgaard and Michael Christiansen

    Citation: Journal of Negative Results in BioMedicine 2011 10:12

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  17. Content type: Research

    When retroperitoneoscopic radical nephrectomy for renal cell carcinoma was introduced into our institution, we performed a combined small skin incision method. In this method, a small incision was made to appr...

    Authors: Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Futoshi Sano, Takayuki Murakami, Narihiko Hayashi, Yasuhide Miyoshi, Noboru Nakaigawa, Masahiro Yao and Yoshinobu Kubota

    Citation: Journal of Negative Results in BioMedicine 2011 10:11

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  18. Content type: Research

    Infectious myonecrosis virus (IMNV) disease outbreaks in cultivated whiteleg shrimp Penaeus (Litopenaeus) vannamei are characterized by gross signs of whitened abdominal muscles and by slow mortality reaching up ...

    Authors: Saengchan Senapin, Kornsunee Phiwsaiya, Warachin Gangnonngiw and Timothy W Flegel

    Citation: Journal of Negative Results in BioMedicine 2011 10:10

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  19. Content type: Research

    MMP28 (epilysin) is a recently discovered member of the MMP (matrix metalloproteinase) family that is, amongst others, expressed in osteoarthritic cartilage and intervertebral disc (IVD) tissue. In this study ...

    Authors: Marina Klawitter, Lilian Quero, Alessando Bertolo, Marco Mehr, Jivko Stoyanov, Andreas G Nerlich, Juergen Klasen, Nikolaus Aebli, Norbert Boos and Karin Wuertz

    Citation: Journal of Negative Results in BioMedicine 2011 10:9

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  20. Content type: Brief report

    Gastrointestinal complaints are common among long distance runners. We hypothesised that small intestinal bacterial overgrowth (SIBO) is present in long distance runners frequently afflicted with gastrointesti...

    Authors: Kai Schommer, Dejan Reljic, Peter Bärtsch and Peter Sauer

    Citation: Journal of Negative Results in BioMedicine 2011 10:8

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  21. Content type: Research

    Histopathological grading of ependymoma has been controversial with respect to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology of 229 intracranial ependymomas from ...

    Authors: David W Ellison, Mehmet Kocak, Dominique Figarella-Branger, Giangaspero Felice, Godfraind Catherine, Torsten Pietsch, Didier Frappaz, Maura Massimino, Jacques Grill, James M Boyett and Richard G Grundy

    Citation: Journal of Negative Results in BioMedicine 2011 10:7

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  22. Content type: Research

    Randomised controlled trials have shown an excellent preventive effect of statins on ischemic heart disease. Our objective was to investigate if a relation can be detected between acute myocardial infarction- ...

    Authors: Staffan Nilsson, Sigvard Mölstad, Catarina Karlberg, Jan-Erik Karlsson and Lars-Göran Persson

    Citation: Journal of Negative Results in BioMedicine 2011 10:6

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  23. Content type: Brief report

    The -945GC polymorphism (rs6918698) in the connective tissue growth factor gene promoter (CTGF/CCN-2) has been associated with end organ damage in systemic sclerosis. Because CTGF is important in progression of d...

    Authors: Amélie Dendooven, Tri Q Nguyen, Lodewijk Brosens, Dongxia Li, Lise Tarnow, Hans-Henrik Parving, Peter Rossing and Roel Goldschmeding

    Citation: Journal of Negative Results in BioMedicine 2011 10:4

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  24. Content type: Research

    Polymorphisms of the vitamin D receptor (VDR) gene have been linked to both multiple sclerosis (MS) and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (V...

    Authors: Chrissa Sioka, Stylianos Papakonstantinou, Sofia Markoula, Foteini Gkartziou, Athanasia Georgiou, Ioannis Georgiou, Sygliti-Henrietta Pelidou, Athanassios P Kyritsis and Andreas Fotopoulos

    Citation: Journal of Negative Results in BioMedicine 2011 10:3

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  25. Content type: Research

    To evaluate the concordance between leisure-time sedentary behavior in adolescents assessed by an activity-based questionnaire and accelerometry.

    Authors: Olivia Affuso, June Stevens, Diane Catellier, Robert G McMurray, Dianne S Ward, Leslie Lytle, Melinda S Sothern and Deborah R Young

    Citation: Journal of Negative Results in BioMedicine 2011 10:2

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  26. Content type: Research

    Methylphenidate blocks the re-uptake of dopamine by binding to the dopamine transporter in the presynaptic cell membrane and increases extracellular dopamine levels. Similarities in neuropsychologic effects be...

    Authors: Richard D Hurt, Jon O Ebbert, Ivana T Croghan, Darrell R Schroeder, Amit Sood and J Taylor Hays

    Citation: Journal of Negative Results in BioMedicine 2011 10:1

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  27. Content type: Research

    The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinoge...

    Authors: Kathrin Scheckenbach, Galatia Papadopoulou, Thomas K Hoffmann, Adam Chaker, Henning Bier, Jörg Schipper, Vera Balz and Martin Wagenmann

    Citation: Journal of Negative Results in BioMedicine 2010 9:10

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  28. Content type: Brief report

    The DNA double strand break repair gene TOPBP1 has been suggested as a breast cancer susceptibility gene and a missense variant Arg309Cys was observed at elevated frequency in familial breast cancer cases compare...

    Authors: Magda A Blaut, Natalia V Bogdanova, Michael Bremer, Johann H Karstens, Peter Hillemanns and Thilo Dörk

    Citation: Journal of Negative Results in BioMedicine 2010 9:9

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  29. Content type: Research

    RNA interference (RNAi) is a powerful approach to study a gene function. Transgenic RNAi is an adaptation of this approach where suppression of a specific gene is achieved by expression of an RNA hairpin from ...

    Authors: Lenka Sarnova, Radek Malik, Radislav Sedlacek and Petr Svoboda

    Citation: Journal of Negative Results in BioMedicine 2010 9:8

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  30. Content type: Research

    Down syndrome (DS) is caused by trisomy of all or part of chromosome 21. To further understanding of DS we are working with a mouse model, the Tc1 mouse, which carries most of human chromosome 21 in addition t...

    Authors: Frances K Wiseman, Olivia Sheppard, Jacqueline M Linehan, Sebastian Brandner, Victor LJ Tybulewicz and Elizabeth MC Fisher

    Citation: Journal of Negative Results in BioMedicine 2010 9:7

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  31. Content type: Research

    Neisseria meningitidis is the second leading cause of invasive meningitis. A prerequisite for infection is colonization of the nasopharynx, and asymptomatic carrier rates are widely reported in the range of 10...

    Authors: Eric J Knudtson, Mike L Lytle, Beverly A Vavricka, Valerie S Skaggs, Jennifer D Peck and Andrew E Elimian

    Citation: Journal of Negative Results in BioMedicine 2010 9:6

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  32. Content type: Research

    Current models suggest that the spectrin cytoskeleton stabilizes interacting ion transport proteins at the plasma membrane. The human erythrocyte anion exchanger (AE1) was the first membrane transport protein ...

    Authors: Ronald R Dubreuil, Amlan Das, Christine Base and G Harper Mazock

    Citation: Journal of Negative Results in BioMedicine 2010 9:5

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  33. Content type: Research

    Schizophrenia is the major psychiatry disorder, which the exact cause remains unknown. However, it is well known that dopamine-mediated neurotransmission imbalance is associated with this pathology and the mai...

    Authors: Bruno R Souza, Karen CL Torres, Débora M Miranda, Bernardo S Motta, Estêvão Scotti-Muzzi, Melissa M Guimarães, Daniel S Carneiro, Daniela VF Rosa, Renan P Souza, Helton J Reis, Andreas Jeromin and Marco A Romano-Silva

    Citation: Journal of Negative Results in BioMedicine 2010 9:4

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  34. Content type: Research

    The present study investigated the effects of venlafaxine, an antidepressant drug with immunoregulatory properties on the inflammatory response and bone loss associated with experimental periodontal disease (E...

    Authors: Rosimary S Carvalho, Carolina M de Souza, Julliana CS Neves, Sergio A Holanda-Pinto, Lívia MS Pinto, Gerly AC Brito and Geanne M de Andrade

    Citation: Journal of Negative Results in BioMedicine 2010 9:3

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  35. Content type: Research

    The transcription factor Oct4 is well defined as a key regulator of embryonic stem (ES) cell pluripotency. In recent years, the role of Oct4 has purportedly extended to the self renewal and maintenance of mult...

    Authors: Zoe Redshaw and Alastair J Strain

    Citation: Journal of Negative Results in BioMedicine 2010 9:2

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  36. Content type: Research

    PALB2 1592delT mutation is associated with increased breast cancer and suggestive prostate cancer (PRCA) risk in Finland. In this study we wanted to assess if any other PALB2 variants associate to increased PRCA ...

    Authors: Sanna Pakkanen, Tiina Wahlfors, Sanna Siltanen, Mimmi Patrikainen, Mika P Matikainen, Teuvo L J Tammela and Johanna Schleutker

    Citation: Journal of Negative Results in BioMedicine 2009 8:12

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  37. Content type: Research

    Mitochondria (mt) are highly susceptible to reactive oxygen species (ROS). In this study, we investigated the association between a region within the displacement loop (D-loop) in mtDNA that is highly suscepti...

    Authors: Jin-Bor Chen, Tsu-Kung Lin, Shang-Chih Liao, Wen-Chin Lee, Lung-Chih Lee, Chia-Wei Liou, Pei-Wen Wang and Mao-Meng Tiao

    Citation: Journal of Negative Results in BioMedicine 2009 8:10

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  38. Content type: Research

    The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.

    Authors: Sushila Jaiswal, Vinita Agrawal, Awadhesh Kumar Jaiswal, Rakesh Pandey and Ashok Kumar Mahapatra

    Citation: Journal of Negative Results in BioMedicine 2009 8:9

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  39. Content type: Research

    Hepatitis C virus (HCV) is a positive-strand RNA virus harboring a highly structured internal ribosome entry site (IRES) in the 5' nontranslated region of its genome. Important for initiating translation of vi...

    Authors: Dominique L Ouellet, Isabelle Plante, Vincent Boissonneault, Cherifa Ayari and Patrick Provost

    Citation: Journal of Negative Results in BioMedicine 2009 8:8

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  40. Content type: Commentary

    We discuss in this commentary a recent Cochrane review of 10 randomised trials aimed at testing the religious belief that praying to a god can help those who are prayed for. The review concluded that the avail...

    Authors: Karsten Juhl Jørgensen, Asbjørn Hróbjartsson and Peter C Gøtzsche

    Citation: Journal of Negative Results in BioMedicine 2009 8:7

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  41. Content type: Research

    In most previous studies the association between number of teeth and cardiovascular diseases has been found to be stronger among younger age groups than in older age groups, which indicates that age may modify...

    Authors: Anna-Maija H Syrjälä, Pekka Ylöstalo, Sirpa Hartikainen, Raimo Sulkava and Matti L Knuuttila

    Citation: Journal of Negative Results in BioMedicine 2009 8:6

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  42. Content type: Research

    A complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionot...

    Authors: Jian Xu, Huai C Yan, Bo Yang, Lu S Tong, Yu X Zou and Ying Tian

    Citation: Journal of Negative Results in BioMedicine 2009 8:5

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  43. Content type: Research

    Serum ferritin and hepatic iron concentrations are frequently elevated in patients who are chronically infected with the hepatitis C virus (HCV), and hepatic iron concentration has been used to predict respons...

    Authors: Ebenezer Tumban, Jenna M Painter and William B Lott

    Citation: Journal of Negative Results in BioMedicine 2009 8:4

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  44. Content type: Research

    Vardenafil (Levitra®) represents a potent and highly selective phosphodiesterase type 5 (PDE5) inhibitor, which is established for treatment of various diseases. There are several unpublished reports from patient...

    Authors: Birgit Mazurek, Heidemarie Haupt, Agnieszka J Szczepek, Jörg Sandmann, Johann Gross, Burghard F Klapp, Holger Kiesewetter, Ulrich Kalus, Timo Stöver and Philipp P Caffier

    Citation: Journal of Negative Results in BioMedicine 2009 8:3

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  45. Content type: Research

    Oxaliplatin is a platinum-based chemotherapeutic drug. Neurotoxicity is the dose-limiting side effect. Previous investigations have reported that acute neurotoxicity could be mediated via voltage-gated ion cha...

    Authors: Amir Broomand, Elin Jerremalm, Jeffrey Yachnin, Hans Ehrsson and Fredrik Elinder

    Citation: Journal of Negative Results in BioMedicine 2009 8:2

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