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  1. Content type: Research

    Drug-induced parkinsonism (DIP) has a high prevalence and is associated with poorer quality of life. To find a practical clinical tool to assess DIP in patients with severe mental illness (SMI), the associatio...

    Authors: Charlotte L. Mentzel, P. Roberto Bakker, Jim van Os, Marjan Drukker, Glenn E. Matroos, Marina A. J. Tijssen and Peter N. van Harten

    Citation: Journal of Negative Results in BioMedicine 2017 16:15

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  2. Content type: Research

    A series of human diseases are caused by the misfolding and aggregation of specific proteins or peptides into amyloid fibrils; nine of these diseases, referred to as polyglutamine diseases, are associated with...

    Authors: Roel Van Assche, Charline Borghgraef, Jonathan Vaneyck, Mireille Dumoulin, Liliane Schoofs and Liesbet Temmerman

    Citation: Journal of Negative Results in BioMedicine 2017 16:14

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  3. Content type: Research

    Work-related stress is a global problem with negative implications for individuals and society. The purpose of the current study was to evaluate a stress management intervention for patients on sick leave due ...

    Authors: Vita Ligaya Dalgaard, Lars Peter Sønderbo Andersen, Johan Hviid Andersen, Morten Vejs Willert, Ole Carstensen and David John Glasscock

    Citation: Journal of Negative Results in BioMedicine 2017 16:13

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  4. Content type: Research

    To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG).

    Authors: Taif A. Azad, Nikhil B. Edward, Altaf A. Kondkar, Hatem Kalantan, Saleh Altuwaijri, Tahira Sultan, Faisal A. Al-Mobarak, Saleh A. Al-Obeidan and Khaled K. Abu-Amero

    Citation: Journal of Negative Results in BioMedicine 2017 16:12

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  5. Content type: Research

    While the positive effect of balance training on age-related impairments in postural stability is well-documented, the neural correlates of such training adaptations in older adults remain poorly understood. T...

    Authors: Jan Ruffieux, Audrey Mouthon, Martin Keller, Michael Wälchli and Wolfgang Taube

    Citation: Journal of Negative Results in BioMedicine 2017 16:11

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  6. Content type: Research

    Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously observed that ...

    Authors: Muhammad M Hammami, Ahmed Yusuf, Faduma S. Shire, Rajaa Hussein and Reem Al-Swayeh

    Citation: Journal of Negative Results in BioMedicine 2017 16:10

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  7. Content type: Research

    In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functiona...

    Authors: Pierre Moffatt, Yeqing Geng, Lisa Lamplugh, Antonio Nanci and Peter J. Roughley

    Citation: Journal of Negative Results in BioMedicine 2017 16:7

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  8. Content type: Research

    Gold compounds have shown promise in the treatment of non-communicable diseases such as rheumatoid arthritis and cancer, and are considered of value as anti-microbial agents against Gram-negative and Gram-posi...

    Authors: Ruqaiyyah Siddiqui, Farhat Abjani, Chien Ing Yeo, Edward R. T. Tiekink and Naveed Ahmed Khan

    Citation: Journal of Negative Results in BioMedicine 2017 16:6

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  9. Content type: Brief report

    We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-m...

    Authors: Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, Gérard Lefranc and Mourad Aribi

    Citation: Journal of Negative Results in BioMedicine 2017 16:9

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  10. Content type: Brief report

    Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very hete...

    Authors: Boubacar Efared, G. Ebang-Atsame, Sani Rabiou, Abdoulsalam S. Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C. Benjelloun, Mounia Serraj, Laila Chbani and Hinde El Fatemi

    Citation: Journal of Negative Results in BioMedicine 2017 16:4

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  11. Content type: Brief report

    The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells di...

    Authors: Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, Hassan Y. Naim and Maren von Köckritz-Blickwede

    Citation: Journal of Negative Results in BioMedicine 2017 16:2

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  12. Content type: Research

    To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).

    Authors: Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A. Azad and Khaled K. Abu-Amero

    Citation: Journal of Negative Results in BioMedicine 2017 16:3

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  13. Content type: Mini-review

    Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from ...

    Authors: Sally Hunter and Carol Brayne

    Citation: Journal of Negative Results in BioMedicine 2017 16:1

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    The Erratum to this article has been published in Journal of Negative Results in BioMedicine 2017 16:8

  14. Content type: Research

    Alzheimer’s disease (AD) is characterized by the pathological deposition of amyloid-β (Aβ) protein-containing plaques. Microglia and astrocytes are commonly attracted to the plaques by an unknown mechanism tha...

    Authors: Anne Schaarschuch, Christoph Redies and Nicole Hertel

    Citation: Journal of Negative Results in BioMedicine 2016 15:22

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  15. Content type: Commentary

    Many psychiatric diseases are influenced by a set of several genetic and environmental factors that genetics alone cannot explain. Specifically, in schizophrenia and bipolar disorder the absence of consistentl...

    Authors: A. Cariaga-Martinez and R. Alelú-Paz

    Citation: Journal of Negative Results in BioMedicine 2016 15:21

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  16. Content type: Research

    Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth ...

    Authors: Matthijs S. Ruiter, Albert Doornbos, Vivian de Waard, Robbert J. de Winter, Nico J. M. Attevelt, Rob Steendam and Carlie J. M. de Vries

    Citation: Journal of Negative Results in BioMedicine 2016 15:20

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  17. Content type: Brief report

    Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipi...

    Authors: G. David Batty, Bruna Galobardes, John M. Starr, Mona Jeffreys, George Davey Smith and Tom C. Russ

    Citation: Journal of Negative Results in BioMedicine 2016 15:19

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  18. Content type: Research

    Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bon...

    Authors: Yaling Liu, Eliane H. Dutra, Ernst J. Reichenberger and I-Ping Chen

    Citation: Journal of Negative Results in BioMedicine 2016 15:18

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  19. Content type: Research

    We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort.

    Authors: Altaf A. Kondkar, Ahmed Mousa, Taif A. Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A. Al-Obeidan and Khaled K. Abu-Amero

    Citation: Journal of Negative Results in BioMedicine 2016 15:17

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  20. Content type: Research

    Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein re...

    Authors: Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan and Rungsunn Tungtrongchitr

    Citation: Journal of Negative Results in BioMedicine 2016 15:16

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  21. Content type: Brief report

    We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease.

    Authors: Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa and Paolo Arcari

    Citation: Journal of Negative Results in BioMedicine 2016 15:14

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  22. Content type: Research

    Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores...

    Authors: Thomas C. Sauter, Stephan Ziegenhorn, Sufian S. Ahmad, Wolf E. Hautz, Meret E. Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G. Haider and Aristomenis K. Exadaktylos

    Citation: Journal of Negative Results in BioMedicine 2016 15:12

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  23. Content type: Brief report

    SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be the equivalent of retinitis...

    Authors: Louise M. Downs, Andrew R. Webster, Anthony T. Moore, Michel Michaelides, Robin R. Ali, Alison J. Hardcastle and Cathryn S. Mellersh

    Citation: Journal of Negative Results in BioMedicine 2016 15:11

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  24. Content type: Research

    Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ...

    Authors: Lukas D. Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner and Christoph Arnoldner

    Citation: Journal of Negative Results in BioMedicine 2016 15:10

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  25. Content type: Brief report

    Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a...

    Authors: Michael W. Calik and David W. Carley

    Citation: Journal of Negative Results in BioMedicine 2016 15:8

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  26. Content type: Research

    Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ...

    Authors: Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut

    Citation: Journal of Negative Results in BioMedicine 2016 15:9

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  27. Content type: Brief report

    Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascula...

    Authors: Julio F. Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos and Kevin Croce

    Citation: Journal of Negative Results in BioMedicine 2016 15:7

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  28. Content type: Research

    Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In...

    Authors: Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai and Toru Nakazawa

    Citation: Journal of Negative Results in BioMedicine 2016 15:5

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  29. Content type: Research

    The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requir...

    Authors: Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus and Lázaro Agustín Vélez

    Citation: Journal of Negative Results in BioMedicine 2016 15:3

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  30. Content type: Research

    Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality.

    Authors: Dominik G. Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C. Sauter, Valentin Fuhrmann and Aristomenis K. Exadaktylos

    Citation: Journal of Negative Results in BioMedicine 2016 15:1

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  31. Content type: Commentary

    Mobile phone use has been discussed over the last few decades with increased risk for intracranial tumors. The majority of studies have been conducted on gliomas and meningiomas. Although some case-control stu...

    Authors: George A. Alexiou and Chrissa Sioka

    Citation: Journal of Negative Results in BioMedicine 2015 14:23

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  32. Content type: Brief report

    Ensuring genetic stability in pluripotent stem cell (PSC) cultures is essential for the development of successful cell therapies. Although most instances lead to failed experiments and go unreported in the lit...

    Authors: Suehelay Acevedo-Acevedo and Wendy C. Crone

    Citation: Journal of Negative Results in BioMedicine 2015 14:22

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  33. Content type: Brief report

    Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d...

    Authors: Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long

    Citation: Journal of Negative Results in BioMedicine 2015 14:21

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  34. Content type: Research

    Ethanol exposure during the rodent equivalent to the 3rd trimester of human pregnancy (i.e., first 1–2 weeks of neonatal life) has been shown to produce structural and functional alterations in the CA3 hippocampa...

    Authors: Brian Charles Baculis and Carlos Fernando Valenzuela

    Citation: Journal of Negative Results in BioMedicine 2015 14:19

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  35. Content type: Brief report

    Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 a...

    Authors: Jennie M. Gane, Robert A. Stockley and Elizabeth Sapey

    Citation: Journal of Negative Results in BioMedicine 2015 14:20

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  36. Content type: Research

    This study aims to better define prognostic factors for patients with metastatic urothelial carcinoma (mUC), and to identify patients who will benefit from first-line cisplatin-based chemotherapy. We test the ...

    Authors: Guilhem Roubaud, Véronique Brouste, Phillipe Beuzeboc, Aude Fléchon, Diego Tosi, Sandrine Lavau-Denes, Christine Chevreau, Stéphane Culine, Stéphane Oudard, Amandine Quivy, Philippe Pourquier and Nadine Houédé

    Citation: Journal of Negative Results in BioMedicine 2015 14:18

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  37. Content type: Brief report

    Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovas...

    Authors: Brynn K. Dredla, Oscar H. Del Brutto, Augustine S. Lee and Pablo R. Castillo

    Citation: Journal of Negative Results in BioMedicine 2015 14:17

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  38. Content type: Brief report

    In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease.

    Authors: Lenka Sedlaříková, Lenka Bešše, Soňa Novosadová, Veronika Kubaczková, Lenka Radová, Michal Staník, Marta Krejčí, Roman Hájek and Sabina Ševčíková

    Citation: Journal of Negative Results in BioMedicine 2015 14:16

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  39. Content type: Research

    Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (...

    Authors: Eskandarain Shafuddin, Graham D. Mills, Mark D. Holmes, Phillippa J. Poole, Peter R. Mullins and Peter N. Black

    Citation: Journal of Negative Results in BioMedicine 2015 14:15

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  40. Content type: Research

    The genome, the environment, and their interactions simultaneously regulate complex traits such as body composition and voluntary exercise levels. One such environmental influence is the maternal milieu (i.e.,...

    Authors: Scott A. Kelly, Kunjie Hua, Jennifer N. Wallace, Sarah E. Wells, Derrick L. Nehrenberg and Daniel Pomp

    Citation: Journal of Negative Results in BioMedicine 2015 14:13

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  41. Content type: Research

    Brain morphometric abnormalities in schizophrenia have been extensively reported in the literature. Whole-brain volumetric reductions are almost universally reported by most studies irrespective of the charact...

    Authors: John P. John, Ammu Lukose, Bhavani Shankara Bagepally, Harsha N. Halahalli, Nagaraj S. Moily, Anupa A. Vijayakumari and Sanjeev Jain

    Citation: Journal of Negative Results in BioMedicine 2015 14:11

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