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  1. Content type: Research

    Keratoconus (KC) is the most common primary ectatic disease of the cornea and a major indication for corneal transplant. To date, limited KC-associated-risk loci have been identified. Association has recently ...

    Authors: Khaled K. Abu-Amero, Inas Helwa, Abdulrahman Al-Muammar, Shelby Strickland, Michael A. Hauser, R. Rand Allingham and Yutao Liu

    Citation: Journal of Negative Results in BioMedicine 2015 14:10

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  2. Content type: Research

    A direct correlation between number of lymph nodes retrieved and evaluated after a colectomy for colorectal cancer and survival of the patient has been reported, and consensus guidelines recommend to assess at...

    Authors: Carlo V Feo, Mattia Portinari, Michele Zuolo, Simone Targa, Vincenzo G Matarese, Roberta Gafà, Elena Forini and Giovanni Lanza

    Citation: Journal of Negative Results in BioMedicine 2015 14:9

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  3. Content type: Brief report

    There is wide variation in the psychosocial response to false-positive mammography. We aimed to assess whether women having to wait longer to exclude cancer had increased psychosocial consequences that persist...

    Authors: Bruno Heleno, Volkert Siersma and John Brodersen

    Citation: Journal of Negative Results in BioMedicine 2015 14:8

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  4. Content type: Research

    Several environmental and genetic factors are associated with high levels of lipids in obese patients. Apolipoprotein B (ApoB) is the major protein component of low-density lipoproteins (LDL), very-low density...

    Authors: Neda M Bogari, Azza M Abdel-Latif, Maha A Hassan, Abeer Ramadan and Ahmed Fawzy

    Citation: Journal of Negative Results in BioMedicine 2015 14:7

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  5. Content type: Research

    It is unknown whether gait biomechanics in hip osteoarthritis patients with mild to moderate symptoms change following exercise therapy interventions. The aim of the present study was to compare stance phase g...

    Authors: Ingrid Eitzen, Linda Fernandes, Lars Nordsletten and May Arna Risberg

    Citation: Journal of Negative Results in BioMedicine 2015 14:5

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  6. Content type: Research

    Tuberculosis (TB) caused by Mycobacterium tuberculosis is the leading cause of death from a bacterial infection. The 4-aminopiperidine (PIP) series has been reported as having anti-bacterial activity against M. t...

    Authors: N Susantha Chandrasekera, Torey Alling, Mai Bailey, Aaron Korkegian, James Ahn, Yulia Ovechkina, Joshua Odingo and Tanya Parish

    Citation: Journal of Negative Results in BioMedicine 2015 14:4

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  7. Content type: Research

    Prior work showed that whole blood, plasma, and serum injections are damaging to the neonatal rodent brain in a model of intracerebral/periventricular hemorrhage. Thrombin alone is also damaging. In adult anim...

    Authors: Xiaoyan Mao and Marc R Del Bigio

    Citation: Journal of Negative Results in BioMedicine 2015 14:3

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  8. Content type: Research

    Osteochondral defects significantly affect patients’ quality of life and represent challenging tissue lesions, because of the poor regenerative capacity of cartilage. Tissue engineering has long sought to prom...

    Authors: Francesca Ravanetti, Carlo Galli, Edoardo Manfredi, Anna Maria Cantoni, Edoardo Scarpa, Guido Maria Macaluso and Antonio Cacchioli

    Citation: Journal of Negative Results in BioMedicine 2015 14:2

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  9. Content type: Research

    Dengue is a major public health problem in many tropical and sub-tropical countries. Vascular leakage and shock are identified as the major causes of deaths in patients with severe dengue. Studies have suggest...

    Authors: Zaiharina Mohamad Zamberi, Zuraihan Zakaria, Abu Thalhah Abdul Aziz, Benedict Sim Lim Heng, Masliza Zaid, Christopher Lee Kwok Chong, Fadzilah Mohd Noor, Sazaly Abu Bakar and Hoh Boon Peng

    Citation: Journal of Negative Results in BioMedicine 2015 14:1

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  10. Content type: Research

    Skeletal muscle undergoes significant atrophy in Type 2 diabetic patients and animal models. We aimed to determine if atrophy of Zucker rat skeletal muscle was due to the activation of intracellular damage pat...

    Authors: Nancy Pompeani, Emma Rybalka, Heidy Latchman, Robyn M Murphy, Kevin Croft and Alan Hayes

    Citation: Journal of Negative Results in BioMedicine 2014 13:19

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  11. Content type: Research

    Rheumatoid arthritis (RA) is an inflammatory disease that leads to destruction of both articular cartilage and bone tissues. In rheumatic joints, synoviocytes and T-lymphocytes as well as bone cells produce th...

    Authors: Sakie Funato, Akihiro Matsunaga, Koei Oh, Yoichi Miyamoto, Kentaro Yoshimura, Junichi Tanaka, Dai Suzuki, Risa Uyama, Hiroaki Suzuki, Kenji Mishima, Masanori Nakamura, Osamu Namiki, Kazuyoshi Baba, Katsunori Inagaki and Ryutaro Kamijo

    Citation: Journal of Negative Results in BioMedicine 2014 13:18

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  12. Content type: Research

    In an earlier study we demonstrated the feasibility to create tissue engineered venous scaffolds in vitro and in vivo. In this study we investigated the use of tissue engineered constructs for ureteral replacemen...

    Authors: Oliver Engel, Robert de Petriconi, Björn G Volkmer, Kilian M Gust, Jens Mani, Axel Haferkamp, Richard E Hautmann and Georg Bartsch

    Citation: Journal of Negative Results in BioMedicine 2014 13:17

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  13. Content type: Research

    P2X7, a purinergic receptor, plays important roles in inflammatory diseases, but recently its expression has been found in several tumors, suggesting a potential role as a cancer cell biomarker. Moreover, the ...

    Authors: Laura Boldrini, Mirella Giordano, Greta Alì, Adele Servadio, Serena Pelliccioni, Cristina Niccoli, Alfredo Mussi and Gabriella Fontanini

    Citation: Journal of Negative Results in BioMedicine 2014 13:16

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  14. Content type: Brief report

    In Changhua County, Taiwan, the number of clinical Acinetobacter baumannii isolates has risen since 2002, and multidrug-resistant Acinetobacter baumannii (MDRAB) has spread rapidly throughout Taiwan. In this stud...

    Authors: Chang-Hua Chen and Chieh-Chen Huang

    Citation: Journal of Negative Results in BioMedicine 2014 13:15

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  15. Content type: Research

    In vivo animal models of familial amyotrophic lateral sclerosis (fALS) are widely used to delineate the potential role that genetic mutations play in the neurodegenerative process. While these models are extensi...

    Authors: Pierre Zwiegers, Grace Lee and Christopher A Shaw

    Citation: Journal of Negative Results in BioMedicine 2014 13:14

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  16. Content type: Research

    Corticoids have potent anti-inflammatory effects, which may help in relieving pain and dysfunction associated with lumbar canal stenosis. We assessed the effectiveness of a decreasing-dose regimen of oral cort...

    Authors: Luiz Claudio L Rodrigues and Jamil Natour

    Citation: Journal of Negative Results in BioMedicine 2014 13:13

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  17. Content type: Research

    Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (...

    Authors: Jan Lötvall, Eric D Bateman, William W Busse, Paul M O’Byrne, Ashley Woodcock, William T Toler, Loretta Jacques, Caroline Goldfrad and Eugene R Bleecker

    Citation: Journal of Negative Results in BioMedicine 2014 13:9

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  18. Content type: Brief report

    The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.

    Authors: Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti and Maria Grazia Porpora

    Citation: Journal of Negative Results in BioMedicine 2014 13:12

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  19. Content type: Research

    Trypanosoma cruzi is the etiological agent of Chagas’ disease that is an endemic disease in Latin America and affects about 8 million people. This parasite belongs to the Trypanosomatidae family which contains a...

    Authors: Otto Kischlat Lacombe, Aline Araujo Zuma, Camila Cristina da Silva, Wanderley de Souza and Maria Cristina M Motta

    Citation: Journal of Negative Results in BioMedicine 2014 13:11

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  20. Content type: Research

    Our assumption that prognosis of patients with traumatic acute subdural hematoma (ASDH) does not differ significantly according to the hemispheric laterality has never been verified.

    Authors: Joji Inamasu, Mitsuhiro Hasegawa, Takuro Hayashi, Yoko Kato and Yuichi Hirose

    Citation: Journal of Negative Results in BioMedicine 2014 13:10

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  21. Content type: Brief report

    With drug treatment for dementia being of limited effectiveness, the role of primary prevention, in particular the predictive value of modifiable cardiovascular disease risk factors, may warrant exploration. T...

    Authors: G David Batty, Tom C Russ, John M Starr, Emmanuel Stamatakis and Mika Kivimäki

    Citation: Journal of Negative Results in BioMedicine 2014 13:8

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  22. Content type: Research

    The antimetabolite chemotherapy 5-Fluorouracil is one of the most commonly prescribed drugs in clinical cancer treatment. Although this drug is not specific for cancer cells and also acts on healthy cells, it ...

    Authors: Tatiani Uceli Maioli, Brenda de Melo Silva, Michelle Nobre Dias, Nivea Carolina Paiva, Valbert Nascimento Cardoso, Simone Odilia Fernandes, Cláudia Martins Carneiro, Flaviano dos Santos Martins and Simone de Vasconcelos Generoso

    Citation: Journal of Negative Results in BioMedicine 2014 13:6

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  23. Content type: Research

    The ADAMs (A Disintegrin and Metalloproteinases) are a family of multi-domain, zinc-dependent metalloproteinase enzymes. ADAM 12 has been previously associated with the onset and progression of breast cancer, ...

    Authors: Erin K Nyren-Erickson, Michael Bouton, Mihir Raval, Jessica Totzauer, Sanku Mallik and Neville Alberto

    Citation: Journal of Negative Results in BioMedicine 2014 13:5

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  24. Content type: Brief report

    Circadian rhythms are known to influence a variety of biological phenomena such as cell cycle, sleep-wake rhythm, hormone release and other important physiological functions. Given that cell cycle entry of hib...

    Authors: Aki Ieyasu, Yoko Tajima, Shigeki Shimba, Hiromitsu Nakauchi and Satoshi Yamazaki

    Citation: Journal of Negative Results in BioMedicine 2014 13:4

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  25. Content type: Research

    The relationship between physical activity (PA) throughout life and the risk of postmenopausal breast cancer overall and by estrogen receptor (ER) and progesterone receptor (PR) status, has been reported, but ...

    Authors: Kristin Benjaminsen Borch, Eiliv Lund, Tonje Braaten and Elisabete Weiderpass

    Citation: Journal of Negative Results in BioMedicine 2014 13:3

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  26. Content type: Reviewer acknowledgement

    A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Journal of Negative Results in BioMedicine has been blessed by...

    Authors: Daniel Shanahan

    Citation: Journal of Negative Results in BioMedicine 2014 13:1

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  27. Content type: Research

    Liver transplantation is the only life-saving therapeutic option for end-stage liver disease. Progressive donor organ shortage and declining donor organ quality justify the evaluation of the leverage of the Do...

    Authors: Benedikt Reichert, Alexander Kaltenborn, Alon Goldis and Harald Schrem

    Citation: Journal of Negative Results in BioMedicine 2013 12:18

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  28. Content type: Research

    NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in Japanese. A previous study has shown that ND2-237 Leu/Met polymorphism modulates the effects o...

    Authors: Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Hirotaka Ochiai, Takako Shirasawa, Hinako Nanri, Hiromi Hoshino and Yutaka Takashima

    Citation: Journal of Negative Results in BioMedicine 2013 12:17

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  29. Content type: Research

    Research on the impact of depression treatment on expenditures is nascent and shows results that vary from negative associations with healthcare expenditures to increased expenditures. However many of these st...

    Authors: Chan Shen, Neel Shah, Patricia A Findley and Usha Sambamoorthi

    Citation: Journal of Negative Results in BioMedicine 2013 12:15

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  30. Content type: Research

    From a mechanistic or physical perspective there is no basis to suspect that electric charges on clusters of air molecules (air ions) would have beneficial or deleterious effects on respiratory function. Yet, ...

    Authors: Dominik D Alexander, William H Bailey, Vanessa Perez, Meghan E Mitchell and Steave Su

    Citation: Journal of Negative Results in BioMedicine 2013 12:14

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  31. Content type: Research

    Rapamycin-induced translocation systems can be used to manipulate biological processes with precise temporal control. These systems are based on rapamycin-induced dimerization of FK506 Binding Protein 12 (FKBP...

    Authors: Jaeda C Coutinho-Budd, Samuel B Snider, Brendan J Fitzpatrick, Joseph E Rittiner and Mark J Zylka

    Citation: Journal of Negative Results in BioMedicine 2013 12:13

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  32. Content type: Research

    The aim of the present study was to explore serological biomarkers which predict the outcome of tonsillectomy for chronic tonsillitis.

    Authors: Silvia Bohne, Robert Siggel, Svea Sachse, Michael Kiehntopf, Michael Bauer, Eberhard Straube and Orlando Guntinas-Lichius

    Citation: Journal of Negative Results in BioMedicine 2013 12:11

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  33. Content type: Research

    Design and execution of immunotherapy trials for seasonal allergies may be complicated by numerous factors including variable allergy testing methods, pollen levels, and timing and intensity of other seasonal ...

    Authors: Kevin Murphy, Sandra Gawchik, David Bernstein, Jens Andersen and Martin Rud Pedersen

    Citation: Journal of Negative Results in BioMedicine 2013 12:10

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  34. Content type: Research

    Guaranà (Paulinia cupana) seed extracts are increasingly popular worldwide for their stimulant, cognitive and behavioral effects. To assess the effects on psychological well-being, anxiety and mood of a commercia...

    Authors: Gianluca Ivan Silvestrini, Franca Marino and Marco Cosentino

    Citation: Journal of Negative Results in BioMedicine 2013 12:9

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  35. Content type: Brief report

    Proteases are well-known virulence factors that promote survival, pathogenesis and immune evasion of many pathogens. Several lines of evidence suggest that the blood–brain barrier permeability is a prerequisit...

    Authors: Junaid Iqbal, Mehak Rajani, Ruqaiyyah Siddiqui and Naveed Ahmed Khan

    Citation: Journal of Negative Results in BioMedicine 2013 12:8

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  36. Content type: Brief report

    C-type natriuretic peptide (CNP) has anti-inflammatory, anti-proliferative, and anti-migratory properties. During the past years, CNP has attained an increasing interest by many research groups, especially in ...

    Authors: Andreas Kuehnl, Jaroslav Pelisek, Martin Bruckmeier, Wajima Safi and Hans-Henning Eckstein

    Citation: Journal of Negative Results in BioMedicine 2013 12:7

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  37. Content type: Research

    Ocular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness. Pedigree analysis suggests the trait has an auto...

    Authors: Paige A Winkler, Joshua T Bartoe, Celeste R Quinones, Patrick J Venta and Simon M Petersen-Jones

    Citation: Journal of Negative Results in BioMedicine 2013 12:6

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  38. Content type: Research

    Rotavirus antigenemia is a common phenomenon in children with rotavirus diarrhea, but information is scarce on aspects of this phenomenon, such as genotype specificity, presence of intact viruses and correlati...

    Authors: Kamruddin Ahmed, Gulendam Bozdayi, Marcelo T Mitui, Selim Ahmed, Luthful Kabir, Dalgic Buket, Ilknur Bostanci and Akira Nishizono

    Citation: Journal of Negative Results in BioMedicine 2013 12:5

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  39. Content type: Research

    Prolactin (PRL) is a hormone synthesized in both the pituitary gland and extrapituitary sites. It has been associated with the occurrence of neoplasms and, more recently, with central nervous system (CNS) neop...

    Authors: Graziella Alebrant Mendes, Júlia Fernanda Semmelmann Pereira-Lima, Maria Beatriz Kohek, Geraldine Trott, Marlise Di Domenico, Nelson Pires Ferreira and Miriam da Costa Oliveira

    Citation: Journal of Negative Results in BioMedicine 2013 12:4

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  40. Content type: Research

    An estimated 10–20 million individuals are infected with the retrovirus human T-cell leukemia virus type 1 (HTLV-1). While the majority of these individuals remain asymptomatic, 0.3-4% develop a neurodegenerat...

    Authors: R Brad Jones, Fabio E Leal, Aaron M Hasenkrug, Aluisio C Segurado, Douglas F Nixon, Mario A Ostrowski and Esper G Kallas

    Citation: Journal of Negative Results in BioMedicine 2013 12:3

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  41. Content type: Research

    The aim of this study was to determine the effects of maternal undernutrition on ovine fetal testis morphology and expression of relevant histological indicators. Maternal undernutrition, in sheep, has been re...

    Authors: Luis P Andrade, Stewart M Rhind, Michael T Rae, Carol E Kyle, Jamie Jowett and Richard G Lea

    Citation: Journal of Negative Results in BioMedicine 2013 12:2

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  42. Content type: Brief report

    Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.

    Authors: Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe and Jesper H Svendsen

    Citation: Journal of Negative Results in BioMedicine 2013 12:1

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  43. Content type: Brief report

    Mental retardation (MR) is a heterogeneous condition that affects 2-3% of the general population and is a public health problem in developing countries. Chromosomal abnormalities are an important cause of MR a...

    Authors: Suely Rodrigues dos Santos and Dértia Villalba Freire-Maia

    Citation: Journal of Negative Results in BioMedicine 2012 11:16

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  44. Content type: Research

    Stone baskets could be easily destroyed by Holmium:YAG-laser at an endourologic treatment, with respect to this, we try to improve the resistance by coating them with a titanium oxide layer. The layer was esta...

    Authors: Jens Cordes, Felix Nguyen, Frank Heidenau and Dieter Jocham

    Citation: Journal of Negative Results in BioMedicine 2012 11:15

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  45. Content type: Research

    Ischemic preconditioning induces tolerance against ischemia-reperfusion injury prior a sustained ischemic insult. In experimental studies, exposure to hyperoxia for a limited time before ischemia induces a low...

    Authors: Inga Karu, Peeter Tähepõld, Arno Ruusalepp, Kersti Zilmer, Mihkel Zilmer and Joel Starkopf

    Citation: Journal of Negative Results in BioMedicine 2012 11:14

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