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  1. Brief report

    Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats

    Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a...

    Michael W. Calik and David W. Carley

    Journal of Negative Results in BioMedicine 2016 15:8

    Published on: 2 May 2016

  2. Research

    Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload

    Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ...

    Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut

    Journal of Negative Results in BioMedicine 2016 15:9

    Published on: 25 April 2016

  3. Brief report

    Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement

    Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascula...

    Julio F. Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos and Kevin Croce

    Journal of Negative Results in BioMedicine 2016 15:7

    Published on: 11 April 2016

  4. Mini-review

    Targeted drugs and Psycho-oncological intervention for breast cancer patients

    Personalized medicine is a new field based on molecular biology and genomics in which targeted tumor therapies are administered to patients. Psycho-oncology is a complementary approach that considers social an...

    Flavio D’Abramo, Ute Goerling and Cecilia Guastadisegni

    Journal of Negative Results in BioMedicine 2016 15:6

    Published on: 1 April 2016

  5. Research

    Topical ocular dexamethasone decreases intraocular pressure and body weight in rats

    Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In...

    Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai and Toru Nakazawa

    Journal of Negative Results in BioMedicine 2016 15:5

    Published on: 12 March 2016

  6. Research

    Comparison of serological methods with PCR-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria

    The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requir...

    Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus and Lázaro Agustín Vélez

    Journal of Negative Results in BioMedicine 2016 15:3

    Published on: 2 March 2016

  7. Research

    Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study

    Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality.

    Dominik G. Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C. Sauter, Valentin Fuhrmann and Aristomenis K. Exadaktylos

    Journal of Negative Results in BioMedicine 2016 15:1

    Published on: 1 February 2016

  8. Commentary

    Mobile phone use and risk for intracranial tumors

    Mobile phone use has been discussed over the last few decades with increased risk for intracranial tumors. The majority of studies have been conducted on gliomas and meningiomas. Although some case-control stu...

    George A. Alexiou and Chrissa Sioka

    Journal of Negative Results in BioMedicine 2015 14:23

    Published on: 23 December 2015

  9. Brief report

    Substrate stiffness effect and chromosome missegregation in hIPS cells

    Ensuring genetic stability in pluripotent stem cell (PSC) cultures is essential for the development of successful cell therapies. Although most instances lead to failed experiments and go unreported in the lit...

    Suehelay Acevedo-Acevedo and Wendy C. Crone

    Journal of Negative Results in BioMedicine 2015 14:22

    Published on: 18 December 2015

  10. Brief report

    Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study

    Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d...

    Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long

    Journal of Negative Results in BioMedicine 2015 14:21

    Published on: 2 December 2015

  11. Research

    Ethanol exposure during the third trimester equivalent does not affect GABAA or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons

    Ethanol exposure during the rodent equivalent to the 3rd trimester of human pregnancy (i.e., first 1–2 weeks of neonatal life) has been shown to produce structural and functional alterations in the CA3 hippocampa...

    Brian Charles Baculis and Carlos Fernando Valenzuela

    Journal of Negative Results in BioMedicine 2015 14:19

    Published on: 2 December 2015

  12. Brief report

    The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study

    Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 a...

    Jennie M. Gane, Robert A. Stockley and Elizabeth Sapey

    Journal of Negative Results in BioMedicine 2015 14:20

    Published on: 1 December 2015

  13. Research

    Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients

    This study aims to better define prognostic factors for patients with metastatic urothelial carcinoma (mUC), and to identify patients who will benefit from first-line cisplatin-based chemotherapy. We test the ...

    Guilhem Roubaud, Véronique Brouste, Phillipe Beuzeboc, Aude Fléchon, Diego Tosi, Sandrine Lavau-Denes, Christine Chevreau, Stéphane Culine, Stéphane Oudard, Amandine Quivy, Philippe Pourquier and Nadine Houédé

    Journal of Negative Results in BioMedicine 2015 14:18

    Published on: 10 November 2015

  14. Brief report

    Willis-Ekbom disease is not associated with poor cardiovascular health in adults

    Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovas...

    Brynn K. Dredla, Oscar H. Del Brutto, Augustine S. Lee and Pablo R. Castillo

    Journal of Negative Results in BioMedicine 2015 14:17

    Published on: 6 November 2015

  15. Brief report

    MicroRNAs in urine are not biomarkers of multiple myeloma

    In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease.

    Lenka Sedlaříková, Lenka Bešše, Soňa Novosadová, Veronika Kubaczková, Lenka Radová, Michal Staník, Marta Krejčí, Roman Hájek and Sabina Ševčíková

    Journal of Negative Results in BioMedicine 2015 14:16

    Published on: 23 September 2015

  16. Research

    A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease

    Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (...

    Eskandarain Shafuddin, Graham D. Mills, Mark D. Holmes, Phillippa J. Poole, Peter R. Mullins and Peter N. Black

    Journal of Negative Results in BioMedicine 2015 14:15

    Published on: 7 September 2015

  17. Research

    Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice

    The genome, the environment, and their interactions simultaneously regulate complex traits such as body composition and voluntary exercise levels. One such environmental influence is the maternal milieu (i.e.,...

    Scott A. Kelly, Kunjie Hua, Jennifer N. Wallace, Sarah E. Wells, Derrick L. Nehrenberg and Daniel Pomp

    Journal of Negative Results in BioMedicine 2015 14:13

    Published on: 3 August 2015

  18. Research

    Sutherlandia frutescens may exacerbate HIV-associated neuroinflammation

    Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. Anti-retroviral (ARV) treatments are rolled out relatively late in the con...

    Luan Dane Africa and Carine Smith

    Journal of Negative Results in BioMedicine 2015 14:14

    Published on: 18 July 2015

  19. Research

    A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

    Brain morphometric abnormalities in schizophrenia have been extensively reported in the literature. Whole-brain volumetric reductions are almost universally reported by most studies irrespective of the charact...

    John P. John, Ammu Lukose, Bhavani Shankara Bagepally, Harsha N. Halahalli, Nagaraj S. Moily, Anupa A. Vijayakumari and Sanjeev Jain

    Journal of Negative Results in BioMedicine 2015 14:11

    Published on: 12 June 2015

  20. Research

    Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population

    Keratoconus (KC) is the most common primary ectatic disease of the cornea and a major indication for corneal transplant. To date, limited KC-associated-risk loci have been identified. Association has recently ...

    Khaled K. Abu-Amero, Inas Helwa, Abdulrahman Al-Muammar, Shelby Strickland, Michael A. Hauser, R. Rand Allingham and Yutao Liu

    Journal of Negative Results in BioMedicine 2015 14:10

    Published on: 4 June 2015

  21. Research

    Preoperative endoscopic tattooing to mark the tumour site does not improve lymph node retrieval in colorectal cancer: a retrospective cohort study

    A direct correlation between number of lymph nodes retrieved and evaluated after a colectomy for colorectal cancer and survival of the patient has been reported, and consensus guidelines recommend to assess at...

    Carlo V Feo, Mattia Portinari, Michele Zuolo, Simone Targa, Vincenzo G Matarese, Roberta Gafà, Elena Forini and Giovanni Lanza

    Journal of Negative Results in BioMedicine 2015 14:9

    Published on: 7 May 2015

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