Retroperitoneoscopic radical nephrectomy with a small incision for renal cell carcinoma: Comparison with the conventional method
© Ito et al; licensee BioMed Central Ltd. 2011
Received: 13 January 2011
Accepted: 16 August 2011
Published: 16 August 2011
When retroperitoneoscopic radical nephrectomy for renal cell carcinoma was introduced into our institution, we performed a combined small skin incision method. In this method, a small incision was made to approach the retroperitoneal space prior to setting trockers and thereafter a LAPDISC was placed in the incision to start the retroperitoneoscopic procedure. In this study, we compared the outcomes between the combined small skin incision method ("A method" hereinafter) and the conventional method ("B method" hereinafter).
material and methods
Among the cases of T1N0M0 suspicious renal cell carcinoma treated at Yokohama City University between May 2003 and June 2009, the A method was performed in 51 cases and the B method was performed in 33 cases. The factors in the outcomes compared between the A and B methods were the duration of procedure, volume of bleeding, volume of transfusion, weight of the specimen, incidence of peritoneal injury, rate of conversion to open surgery, and perioperative complications.
The duration of the procedure was 214.4 ± 46.9 minutes in the A method group and 208.1 ± 36.4 minutes in the B method group (p = 0.518). The volume of bleeding and the weight of the specimen were 105.5 ± 283.2 ml and 335.1 ± 137.4 g in the A method group and 44.8 ± 116 ml (p = 0.247) and 309.2 ± 126 g (p = 0.385) in the B method group. There was no significant difference in all factors analyzed.
The A method would be highly possible to produce stable results, even during the introduction period when the staff and the institution are still unfamiliar with the retroperitoneoscopic surgery.
Keywordsthe retroperitoneoscopic radical nephrectomy method with a small incision surgical outcome
The technical progress in laparoscopic surgery for renal cell carcinoma has been remarkable. Many institutions have introduced laparoscopic radical nephrectomy for renal cell carcinoma and even retroperitoneoscopic radical nephrectomy for renal cell carcinoma . In recent years, these surgical methods are in widespread use, and the number of reports [2, 3] about complications associated with surgery is rising. It has become important to identify how such a surgery can be completed in a safe manner during the introduction period when institutions and staff are still unfamiliar with these surgical methods.
When retroperitoneoscopic radical nephrectomy for renal cell carcinoma was introduced into our institution, we performed a combined small skin incision method in our hospital. That's because we thought that the combined small skin incision method was safer than the conventional method that all procedures were performed with laparoscopic instruments. In this study, we compared the outcomes between the combined small skin incision method ("A method" hereinafter) and the conventional method ("B method" hereinafter).
Material and methods
Among the cases of suspicious T1N0M0 renal cell carcinoma treated at Yokohama City University between May 2003 and June 2009, the A method was performed in 51 cases (preoperative diagnosis was T1a in 30 cases and T1b in 21 cases) and the B method was performed in 33 cases (preoperative diagnosis was T1a in 20 cases and T1b in 13 cases). The A method was performed during the period between May 2003 and January 2008 and the B method was performed during the period between September 2007 and June 2009. The period between September 2007 and January 2008 was a period of transition from the A method to the B method. During this period, the A method was performed in 8 cases while the B method was performed in 5 cases. A total of six surgeons handled these cases, and the A method was employed by six surgeons while the B method was employed by four surgeons.
According to the criteria applied in our hospital for selecting the surgical method for renal cell carcinoma, the main indication for retroperitoneoscopic radical nephrectomy for renal cell carcinoma is T1N0M0 renal cell carcinoma. That's because we thought that laparoscopic approach caused peritoneal adhesion more than retroperitoneoscopic approach. In T2-T3aN0M0 renal cell carcinoma as well as in T1 tumours located dorsally, a laparoscopic approach is preferred. Furthermore, it has been reported recently that partial nephrectomy for renal cell carcinoma exhibits higher efficiency , and thus open partial nephrectomy or laparoscopic partial nephrectomy is more frequently performed in the treatment of T1a renal cell carcinoma in our hospital .
The factors in the outcomes compared between the A and B methods were the duration of procedure, volume of bleeding, volume of transfusion, weight of the specimen, incidence of peritoneal injury, rate of conversion to laparotomy, and perioperative complications. The Student's t- test and the Fisher's exact test were used in the analysis.
demographic and tumor data
mean age ± SD
62.55 ± 12.22
60.88 ± 14.46
mean body height ± SD (cm)
162.7 ± 8.9
162.8 ± 11.1
mean body weight ± SD (kg)
64.6 ± 14.6
58.1 ± 12.2
mean BMI ± SD
24.3 ± 3.85
21.9 ± 3.58
preoperative tumor diameter ± SD(mm)
40.5 ± 12.6
40 ± 11.7
clinical T stage and pahological data
preoperative clinical T stage
microscopic venous invasion
pathological T stage
Histological data and nuclear grade was available. In the A method, 84.3% had clear cell tumors, and 15.7% had other histologies, on the other hand, 78.7% had clear cell tumors, and 21.3% had other histologies in the B method. In the former, Pathological nuclear grade was 1 in 29.4%, 2 in 51%, 3 in 13.7%, and in the latter, that grade was 1 in 24.2%, 2 in 60.6%, 3 in 3%.
In the A method group, complications were found in 4 cases: a descending mesocolon injury in 1 case, a renal vein injury in 1 case, damage to the renal cortex in 1 case, and damage to the inferior surface of the liver in 1 case. In the B method group, complications were found in 1 case: a renal vein injury in 1 case. Open conversion was found in 1 case in each group: the case of damage to the renal cortex in the A method group and the case of renal vein injury in the B method group. Blood transfusion was required in 2 cases in the B method group: 1 case of pre-surgery anemia and 1 case of renal vein injury. Peritoneal injury was identified in 15 cases in the A method group (29.4%) and 8 cases in the B method group (24.2%) (p = 0.803).
intraoperative and postoperative parameters between A method and B method
mean operative time ± SD (min)
214.4 ± 46.9
208.1 ± 36.4
blood loss ± SD (ml)
105.5 ± 283.2
44.8 ± 116
blood transfusion ± SD (unit)
0.242 ± 1.09
weight of specimens ± SD (g)
335.1 ± 137.4
309.2 ± 126
Retroperitoneoscopic surgery must be performed in a narrow operative space and is thus said to be technically difficult to perform, and therefore laparoscopic surgery was recommended in the past . However, the invention of atraumatic balloon dilation has made it easier to secure a space , and retroperitoneoscopic surgery has been in widespread use in recent years . Many reports have presented results of a comparison of retroperitoneoscopic surgery with open surgery and laparoscopic surgery, and the studies concluded that retroperitoneoscopic radical nephrectomy is in no way inferior to other traditional surgical methods [9, 10]. It is certain that there have been significant technical improvements in retroperitoneoscopic surgery. At the same time, there are also reports on the existence of learning curves . Tobias-Machado M et. al.  reported that a clear learning curve was obtained in the initial 15 cases.
Inderbir S. Gill et. al.  compared the outcomes of a laparoscopic partial nephrectomy for renal cell carcinoma soon after introducing it into their institution with the outcomes of an open laparoscopic partial nephrectomy for renal cell carcinoma, and reported that the incidence of intraoperative complications was significantly higher in laparoscopic surgery. This indicates that laparoscopic partial nephrectomy for renal cell carcinoma is technically difficult to perform. Furtheremore, however laparoscopic surgery is said to be safer, that may also induce complications. The complications tend to be occurred particularly when laparoscopic surgery is performed during the introduction period when surgeons and medical staff are still unfamiliar with this surgical method and when learning curves have not yet been determined.
Safer laparoscopic surgical methods, such as hand-assisted laparoscopic surgery, have now been devised  and it has been proved that these methods are less invasive than open surgery. The A method was similar to this hand-assisted laparoscopic surgery. But the A method could be better than hond-assited method in terms of being able to using abdominal air pressure to prevent bleedeing. The A method was performed at the time of introduction of retroperitoneoscopic surgery into our institution and it was possible to obtain stable results.
One of the advantages of the A method could be safety. Since it is possible to remove the flank pad and to access the retroperitoneal space under one's direct vision, it is easier to understand the orientation, and it is possible to more promptly facilitate open conversion in cases of massive bleeding. However, the open conversion in 1 case of the A method was not emergent but selective. So, we were fortunately not given an opportunity to perform it in order to stop massive bleeding.
On the other hand, one of the disadvantages of the A method is larger size of the incision. The incision, which is about 7 cm, is larger than the approximately 5 cm incision in the traditional methods, and the preceding incision limits port sites. In particular, limits of port sites were more prominent with thinner patients and disturbed the surgical procedures in quite a few cases.
In this study, there was no difference in surgical outcomes between the A method and the B method for renal cell carcinoma. Since there was no difference in the outcomes between the A method at the time of introduction of retroperitoneoscopic surgery and the B method when the staff had become familiar with retroperitoneoscopic surgery, it was indicated that the A method could be safer. In addition, we had to state that we have limitations in this study because of small sample size included. Such a small number of sample included in this study might be related to a lack of statistical power. That could induce no difference between the two groups in surgical outcomes.
This study identified no large differences in the outcomes between the retroperitoneoscopic radical nephrectomy method with a small incision for renal cell carcinoma and the standard method.
It would be highly possible to produce stable results, even during the introduction period when the staff and the institution are still unfamiliar with the retroperitoneoscopic surgery, by applying the procedure of a combined small skin incision.
- A method:
Retroperitoneoscopic radical nephrectomy with a small incision
- B method:
Standard way of retroperitoneoscopic radical nephrectomy.
- Hollingsworth JM, Miller DC, Dunn RL, Montgomery JS, Roberts WW, Hafez KS, Wolf JS: Surgical management of low-stage renal cell carcinoma: Technology does not supersede biology. Urology. 2006, 67 (6): 1175-80. 10.1016/j.urology.2006.01.008.View ArticlePubMedGoogle Scholar
- Liapis D, de la Taille A, Ploussard G, Robert G, Bastien L, Hoznek A, Vordos D, Abbou C, Salomon L: Analysis of complications from 600 retroperitoneoscopic procedures of the upper urinary tract during the last 10 years. World J Urol. 2008, 26 (6): 523-30. 10.1007/s00345-008-0319-3.View ArticlePubMedPubMed CentralGoogle Scholar
- Pareek G, Hedican SP, Gee JR, Bruskewitz RC, Nakada SY: Meta-analysis of the complications of laparoscopic renal surgery: comparison of procedures and techniques. J Urol. 2006, 175: 1208-13. 10.1016/S0022-5347(05)00639-7.View ArticlePubMedGoogle Scholar
- Makiyama K, Fujinami K, Suzuki K, Sugiura S, Teranishi J, Sano F, Saito K, Noguchi K, Kubota Y: Safe retroperitoneoscopic radical nephrectomy with small incision for renal cell carcinoma. Nippon Hinyokika Gakkai Zasshi. 2004, 95 (4): 669-74.PubMedGoogle Scholar
- Makiyama K, Nakaigawa N, Miyoshi Y, Kubota Y, Suzuki K, Kishida K, Noguchi K, Kitami K, Kobayashi K, Moriyama M: Retroperitoneoscopic radical nephrectomy with small incision for renal cell carcinoma -Learning curve and complications-. Jpn J Endourol ESWL. 2006, 19: 82-86.Google Scholar
- Fergany AF, Hafez KS, Novick AC: Long-term results of nephron sparing surgery for localized renal cell carcinoma:10-year followup. J Urol. 2000, 163 (2): 442-5. 10.1016/S0022-5347(05)67896-2.View ArticlePubMedGoogle Scholar
- Makiyama K, Nakaigawa N, Miyoshi Y, Murakami T, Ogawa T, Uemura H, Yao M, Kubota Y: Laparoscopic surgery for renal cell carcinoma in view of QOL. Hinyoukigeka. 2007, 20 (Rinzou): 497-499.Google Scholar
- Gill IS, Schweizer D, Hobart MG, Sung GT, Klein EA, Novick AC: Retroperitoneal laparoscopic radical nephrectomy: the Cleveland clinic experience. J Urol. 2000, 163: 1665-70. 10.1016/S0022-5347(05)67516-7.View ArticlePubMedGoogle Scholar
- Desai MM, Strzempkowski B, Matin SF, Steinberg AP, Ng C, Meraney AM, Kaouk JH, Gill IS: Prospective randomized comparison of transperitoneal versus retroperitoneal laparoscopic radical nephrectomy. J Urol. 2005, 173 (1): 38-41. 10.1097/01.ju.0000145886.26719.73.View ArticlePubMedGoogle Scholar
- Gratzke C, Seitz M, Bayrle F, Schlenker B, Bastian PJ, Haseke N, Bader M, Tilki D, Roosen A, Karl A, Reich O, Khoder WY, Wyler S, Stief CG, Staehler M, Bachmann A: Quality of life and perioperative outcomes after retroperitoneoscopic radical nephrectomy (RN), open RN and nephron-sparing surgery in patients with renal cell carcinoma. BJU Int. 2009, 104 (4): 470-5. 10.1111/j.1464-410X.2009.08439.x.View ArticlePubMedGoogle Scholar
- Tobias-Machado M, Ravizzini PI, Pertusier LO, Pedroso E, Wroclawski ER: Prospective comparative study between retroperitoneoscopic and hand-assisted laparoscopic approach for radical nephrectomy. Int Braz J Urol. 2009, 35 (3): 284-91. discussion 291-2View ArticlePubMedGoogle Scholar
- Gill IS, Matin SF, Desai MM, Kaouk JH, Steinberg A, Mascha E, Thornton J, Sherief MH, Strzempkowski B, Novick AC: Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients. J Urol. 2003, 170 (1): 64-8. 10.1097/01.ju.0000072272.02322.ff.View ArticlePubMedGoogle Scholar
- Tanaka M, Tokuda N, Koga H, Yokomizo A, Sakamoto N, Naito S: Hand assisted laparoscopic radical nephrectomy for renal carcinoma using a new abdominal wall sealing device. J Urol. 2000, 164 (2): 314-8. 10.1016/S0022-5347(05)67348-X.View ArticlePubMedGoogle Scholar
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