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  1. Research

    Absence of the dermatan sulfate chain of decorin does not affect mouse development

    In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functiona...

    Pierre Moffatt, Yeqing Geng, Lisa Lamplugh, Antonio Nanci and Peter J. Roughley

    Journal of Negative Results in BioMedicine 2017 16:7

    Published on: 17 April 2017

  2. Research

    The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype

    Gold compounds have shown promise in the treatment of non-communicable diseases such as rheumatoid arthritis and cancer, and are considered of value as anti-microbial agents against Gram-negative and Gram-posi...

    Ruqaiyyah Siddiqui, Farhat Abjani, Chien Ing Yeo, Edward R. T. Tiekink and Naveed Ahmed Khan

    Journal of Negative Results in BioMedicine 2017 16:6

    Published on: 3 April 2017

  3. Brief report

    Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src

    We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-m...

    Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, Gérard Lefranc and Mourad Aribi

    Journal of Negative Results in BioMedicine 2017 16:9

    Published on: 20 March 2017

  4. Brief report

    The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases

    Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very hete...

    Boubacar Efared, G. Ebang-Atsame, Sani Rabiou, Abdoulsalam S. Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C. Benjelloun, Mounia Serraj, Laila Chbani and Hinde El Fatemi

    Journal of Negative Results in BioMedicine 2017 16:4

    Published on: 1 March 2017

  5. Brief report

    Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus

    The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells di...

    Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, Hassan Y. Naim and Maren von Köckritz-Blickwede

    Journal of Negative Results in BioMedicine 2017 16:2

    Published on: 19 February 2017

  6. Research

    Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients

    To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).

    Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A. Azad and Khaled K. Abu-Amero

    Journal of Negative Results in BioMedicine 2017 16:3

    Published on: 2 February 2017

  7. Mini-review

    Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?

    Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from ...

    Sally Hunter and Carol Brayne

    Journal of Negative Results in BioMedicine 2017 16:1

    Published on: 26 January 2017

    The Erratum to this article has been published in Journal of Negative Results in BioMedicine 2017 16:8

  8. Research

    Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries

    Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth ...

    Matthijs S. Ruiter, Albert Doornbos, Vivian de Waard, Robbert J. de Winter, Nico J. M. Attevelt, Rob Steendam and Carlie J. M. de Vries

    Journal of Negative Results in BioMedicine 2016 15:20

    Published on: 5 December 2016

  9. Brief report

    Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study

    Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipi...

    G. David Batty, Bruna Galobardes, John M. Starr, Mona Jeffreys, George Davey Smith and Tom C. Russ

    Journal of Negative Results in BioMedicine 2016 15:19

    Published on: 2 November 2016

  10. Research

    Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia

    Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bon...

    Yaling Liu, Eliane H. Dutra, Ernst J. Reichenberger and I-Ping Chen

    Journal of Negative Results in BioMedicine 2016 15:18

    Published on: 26 October 2016

  11. Research

    Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort

    We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort.

    Altaf A. Kondkar, Ahmed Mousa, Taif A. Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A. Al-Obeidan and Khaled K. Abu-Amero

    Journal of Negative Results in BioMedicine 2016 15:17

    Published on: 29 September 2016

  12. Research

    Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women

    Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein re...

    Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan and Rungsunn Tungtrongchitr

    Journal of Negative Results in BioMedicine 2016 15:16

    Published on: 1 September 2016

  13. Brief report

    Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer

    We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease.

    Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa and Paolo Arcari

    Journal of Negative Results in BioMedicine 2016 15:14

    Published on: 25 July 2016

  14. Research

    Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation

    Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores...

    Thomas C. Sauter, Stephan Ziegenhorn, Sufian S. Ahmad, Wolf E. Hautz, Meret E. Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G. Haider and Aristomenis K. Exadaktylos

    Journal of Negative Results in BioMedicine 2016 15:12

    Published on: 1 June 2016

  15. Brief report

    Investigation of SLA4A3 as a candidate gene for human retinal disease

    SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be the equivalent of retinitis...

    Louise M. Downs, Andrew R. Webster, Anthony T. Moore, Michel Michaelides, Robin R. Ali, Alison J. Hardcastle and Cathryn S. Mellersh

    Journal of Negative Results in BioMedicine 2016 15:11

    Published on: 23 May 2016

  16. Research

    Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

    Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ...

    Lukas D. Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner and Christoph Arnoldner

    Journal of Negative Results in BioMedicine 2016 15:10

    Published on: 11 May 2016

  17. Brief report

    Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats

    Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a...

    Michael W. Calik and David W. Carley

    Journal of Negative Results in BioMedicine 2016 15:8

    Published on: 2 May 2016

  18. Research

    Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload

    Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ...

    Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut

    Journal of Negative Results in BioMedicine 2016 15:9

    Published on: 25 April 2016

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