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  1. Brief report

    Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus

    The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells di...

    Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, Hassan Y. Naim and Maren von Köckritz-Blickwede

    Journal of Negative Results in BioMedicine 2017 16:2

    Published on: 19 February 2017

  2. Research

    Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients

    To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).

    Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A. Azad and Khaled K. Abu-Amero

    Journal of Negative Results in BioMedicine 2017 16:3

    Published on: 2 February 2017

  3. Research

    Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries

    Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth ...

    Matthijs S. Ruiter, Albert Doornbos, Vivian de Waard, Robbert J. de Winter, Nico J. M. Attevelt, Rob Steendam and Carlie J. M. de Vries

    Journal of Negative Results in BioMedicine 2016 15:20

    Published on: 5 December 2016

  4. Brief report

    Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study

    Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipi...

    G. David Batty, Bruna Galobardes, John M. Starr, Mona Jeffreys, George Davey Smith and Tom C. Russ

    Journal of Negative Results in BioMedicine 2016 15:19

    Published on: 2 November 2016

  5. Research

    Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia

    Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bon...

    Yaling Liu, Eliane H. Dutra, Ernst J. Reichenberger and I-Ping Chen

    Journal of Negative Results in BioMedicine 2016 15:18

    Published on: 26 October 2016

  6. Research

    Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort

    We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort.

    Altaf A. Kondkar, Ahmed Mousa, Taif A. Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A. Al-Obeidan and Khaled K. Abu-Amero

    Journal of Negative Results in BioMedicine 2016 15:17

    Published on: 29 September 2016

  7. Research

    Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women

    Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein re...

    Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan and Rungsunn Tungtrongchitr

    Journal of Negative Results in BioMedicine 2016 15:16

    Published on: 1 September 2016

  8. Brief report

    Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer

    We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease.

    Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa and Paolo Arcari

    Journal of Negative Results in BioMedicine 2016 15:14

    Published on: 25 July 2016

  9. Research

    Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation

    Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores...

    Thomas C. Sauter, Stephan Ziegenhorn, Sufian S. Ahmad, Wolf E. Hautz, Meret E. Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G. Haider and Aristomenis K. Exadaktylos

    Journal of Negative Results in BioMedicine 2016 15:12

    Published on: 1 June 2016

  10. Brief report

    Investigation of SLA4A3 as a candidate gene for human retinal disease

    SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be the equivalent of retinitis...

    Louise M. Downs, Andrew R. Webster, Anthony T. Moore, Michel Michaelides, Robin R. Ali, Alison J. Hardcastle and Cathryn S. Mellersh

    Journal of Negative Results in BioMedicine 2016 15:11

    Published on: 23 May 2016

  11. Research

    Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

    Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ...

    Lukas D. Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner and Christoph Arnoldner

    Journal of Negative Results in BioMedicine 2016 15:10

    Published on: 11 May 2016

  12. Brief report

    Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats

    Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a...

    Michael W. Calik and David W. Carley

    Journal of Negative Results in BioMedicine 2016 15:8

    Published on: 2 May 2016

  13. Research

    Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload

    Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ...

    Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut

    Journal of Negative Results in BioMedicine 2016 15:9

    Published on: 25 April 2016

  14. Brief report

    Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement

    Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascula...

    Julio F. Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos and Kevin Croce

    Journal of Negative Results in BioMedicine 2016 15:7

    Published on: 11 April 2016

  15. Mini-review

    Targeted drugs and Psycho-oncological intervention for breast cancer patients

    Personalized medicine is a new field based on molecular biology and genomics in which targeted tumor therapies are administered to patients. Psycho-oncology is a complementary approach that considers social an...

    Flavio D’Abramo, Ute Goerling and Cecilia Guastadisegni

    Journal of Negative Results in BioMedicine 2016 15:6

    Published on: 1 April 2016

  16. Research

    Topical ocular dexamethasone decreases intraocular pressure and body weight in rats

    Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In...

    Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai and Toru Nakazawa

    Journal of Negative Results in BioMedicine 2016 15:5

    Published on: 12 March 2016

  17. Research

    Comparison of serological methods with PCR-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria

    The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requir...

    Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus and Lázaro Agustín Vélez

    Journal of Negative Results in BioMedicine 2016 15:3

    Published on: 2 March 2016

  18. Research

    Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study

    Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality.

    Dominik G. Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C. Sauter, Valentin Fuhrmann and Aristomenis K. Exadaktylos

    Journal of Negative Results in BioMedicine 2016 15:1

    Published on: 1 February 2016

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