Fig. 1From: A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary diseaseCONSORT diagram of the flow of participants. All randomised participants were included in the analysis. The subjects who had withdrawn from the study medication remained for the full assessment period and were reviewed at the final visit day, as far as possibleBack to article page