A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

Table 3 Brain regions showing volumetric reductions in schizophrenia subjects at a significance threshold of p < 0.001 uncorrected and an extent threshold of 0 voxels, with total brain volume (TBV), age and gender entered in the two sample random effects analysis (RFX) as co-variates

No.	Brain Areas	X coordinate	Y coordinate	Z coordinate	Z-score
1	Left Limbic Lobe, Parahippocampal Gyrus^a	−20.38	−18.92	−7.32	3.95225
3	Left Inferior Frontal Gyrus^b	−34.13	19.15	−6.65	3.7467
6	Right Limbic Lobe Parahippocampal Gyrus	22.73	−15.82	−11.7	3.49583
7	Left Cerebellum, Posterior Lobe, Uvula	−32.85	−73.57	−24.87	3.46501
8	Left Middle Frontal Gyrus	−26.49	5.75	43.56	3.45607
9	Left Limbic Lobe, Posterior Cingulate	0.14	−44.61	9.51	3.44248
10	Right Limbic Lobe, Uncus	27.19	−8.16	−32.52	3.40087
11	Right Cerebellum, Anterior Lobe Culmen	22.72	−39.19	−17.97	3.38461
12	Right Middle Temporal Gyrus	50.82	1.49	−31.21	3.3579
13	Left Middle Occipital Gyrus	−36.02	−83.29	2.53	3.3346
14	Left Inferior Occipital Gyrus	−26.18	−87.88	−8.55	3.28956
15	Left Cerebellum, Posterior Lobe, Declive^a	−28.71	−68.27	−21.59	3.25773
17	Right Cerebellum	1.71	−78.86	−15.33	3.22923
18	Left Limbic Lobe, Parahippocampal Gyrus	−18.81	1.55	−14.81	3.21702
19	Right Sub-lobar, Insula	45.9	−28.73	18.55	3.18732
20	Left Cerebellum, Posterior Lobe, Tuber	−39.78	−66.55	−24.32	3.17812
21	Left Inferior Frontal Gyrus	−25.68	8.97	−18.28	3.11841
22	Right Superior Frontal Gyrus	16.93	55	28.69	3.11632
23	Left Cerebellum, Anterior Lobe, Culmen	−21.71	−45.94	−19.36	3.10443
24	Right Limbic Lobe Parahippocampal Gyrus	33.85	−17.15	−12.99	3.10001

^a2 clusters significant at p < 0.001 uncorrected; cluster with higher z-score listed
^b3 clusters significant at p < 0.001 uncorrected; cluster with higher z-score listed

ISSN: 1477-5751