A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

Table 2 Brain regions showing volumetric reductions in schizophrenia subjects at a significance threshold of p < 0.001 uncorrected and an extent threshold of 0 voxels when no co-variates were entered in the two sample random effects analysis (RFX)

No.	Brain areas	X coordinate	Y coordinate	Z coordinate	Z-score
1	Left Limbic Lobe	−20.37	−17.52	−7.19	4.10988
2	Left Limbic Lobe Parahippocampal Gyrus	−35.56	−11.33	−12.26	3.33252
3	Left Inferior Frontal Gyrus^a	−32.72	20.67	−7.83	3.77623
6	Left Posterior Cingulate^b	0.14	−44.61	9.51	3.60518
8	Right Limbic Lobe Parahippocampal Gyrus	21.34	−15.82	−11.72	3.57726
9	Right Limbic Lobe Uncus	28.59	−6.77	−32.37	3.50207
10	Right Middle Temporal Gyrus^b	50.82	1.49	−31.21	3.49174
12	Left Cerebellum Posterior Lobe Uvula	−32.88	−75.1	−23.66	3.4462
13	Left Middle Frontal Gyrus	−26.49	5.75	43.56	3.37068
14	Left Middle Occipital Gyrus	−36.02	−83.29	2.53	3.30096
15	Right Cerebellum, Anterior Lobe, Culmen	24.13	−39.06	−19.28	3.28409
16	Right Occipital Lobe, Cuneus	1.3	−91.52	13.2	3.2631
17	Left Limbic Lobe Parahippocampal Gyrus	−18.81	1.55	−14.81	3.24654
18	Right Cerebellum	3.1	−78.87	−15.3	3.23652
19	Left Cerebellum, Posterior Lobe, Declive	−28.73	−65	−20.12	3.21802
20	Right Sub-lobar Insula	43.12	−30.12	18.37	3.21794
21	Left Cerebellum, Posterior Lobe, Tuber	−39.78	−66.55	−24.32	3.2137
22	Right Occipital Lobe, Lingual Gyrus	4.24	−93.02	−0.41	3.21088
23	Left Temporal Lobe, Sub-Gyral	−38.28	−2.67	−14.19	3.19289
24	Left Inferior Occipital Gyrus	−27.58	−88.01	−7.23	3.14937
25	Left Temporal Lobe Fusiform Gyrus^b	−50.88	−45.92	−18.5	3.1054

^a3 clusters significant at p < 0.001 uncorrected; cluster with higher z-score listed
^b2 clusters significant at p < 0.001 uncorrected; cluster with higher z-score listed

ISSN: 1477-5751