Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population

Table 3 Association between CCT-associated SNPs and KC risk in the Saudi Arabian study population

Locus	Lead SNP	A1/A2	MA	MAF Case	MAF Control	p-value	OR (95 % CI)
COL4A3	rs7606754	A/G	A	0.35	0.37	0.6	0.9 (0.7-1.3)
FNDC3B	rs4894535	C/T	T	0.16	0.12	0.1	1.4 (0.9-2,2)
MPDZ-NF1B	rs1324183	A/C	A	0.25	0.28	0.4	0.8 (0.8-1.2)
RXRA-COL5A1	rs1536482	A/G	A	0.45	0.41	0.4	1.1 (0.8-1.6)
COL5A1	rs7044529	C/T	T	0.14	0.13	0.8	1.1 (0.7-1.7)
LCN12-PTGDS	rs11145951	C/T	T	0.44	0.49	0.2	0.8 (0.6-1.1)
FOXO1	rs2721051	C/T	T	0.14	0.11	0.2	1.4 (0.9-2.2)
BANP-ZNF49	rs9938149	A/C	C	0.29	0.32	0.4	0.9 (0.6-1.2)

CCT Central cornea thickness; SNP single nucleotide polymorphism; KC keratoconus; A1/A2 Allele 1/Allele 2; MA minor allele; MAF minor allele frequency; p-value, derived from two-tailed fisher exact test; OR odds ratio; CI confidence interval. COL4A3 Collagen, type IV, alpha (Goodpasture antigen); FNDC3B fibronectin type III domain containing 3B; MPDZ multiple PDZ domain protein; NF1B neurofibromin 1b; COL5A1 collagen, type V, alpha 1; LCN12 lipocalin 12; PTGDS prostaglandin D2 synthase 21 kDa; FOXO1 forkhead box O1; BANP BTG3 associated nuclear protein; ZNF469 zinc finger protein 469

ISSN: 1477-5751