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Table 3 Association between CCT-associated SNPs and KC risk in the Saudi Arabian study population

From: Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population

Locus Lead SNP A1/A2 MA MAF Case MAF Control p-value OR (95 % CI)
COL4A3 rs7606754 A/G A 0.35 0.37 0.6 0.9 (0.7-1.3)
FNDC3B rs4894535 C/T T 0.16 0.12 0.1 1.4 (0.9-2,2)
MPDZ-NF1B rs1324183 A/C A 0.25 0.28 0.4 0.8 (0.8-1.2)
RXRA-COL5A1 rs1536482 A/G A 0.45 0.41 0.4 1.1 (0.8-1.6)
COL5A1 rs7044529 C/T T 0.14 0.13 0.8 1.1 (0.7-1.7)
LCN12-PTGDS rs11145951 C/T T 0.44 0.49 0.2 0.8 (0.6-1.1)
FOXO1 rs2721051 C/T T 0.14 0.11 0.2 1.4 (0.9-2.2)
BANP-ZNF49 rs9938149 A/C C 0.29 0.32 0.4 0.9 (0.6-1.2)
  1. CCT Central cornea thickness; SNP single nucleotide polymorphism; KC keratoconus; A1/A2 Allele 1/Allele 2; MA minor allele; MAF minor allele frequency; p-value, derived from two-tailed fisher exact test; OR odds ratio; CI confidence interval. COL4A3 Collagen, type IV, alpha (Goodpasture antigen); FNDC3B fibronectin type III domain containing 3B; MPDZ multiple PDZ domain protein; NF1B neurofibromin 1b; COL5A1 collagen, type V, alpha 1; LCN12 lipocalin 12; PTGDS prostaglandin D2 synthase 21 kDa; FOXO1 forkhead box O1; BANP BTG3 associated nuclear protein; ZNF469 zinc finger protein 469