|
Locus
|
Lead SNP
|
A1/A2
|
MA
|
MAF Case
|
MAF Control
|
p-value
|
OR (95 % CI)
|
|---|
|
COL4A3
|
rs7606754
|
A/G
|
A
|
0.35
|
0.37
|
0.6
|
0.9 (0.7-1.3)
|
|
FNDC3B
|
rs4894535
|
C/T
|
T
|
0.16
|
0.12
|
0.1
|
1.4 (0.9-2,2)
|
|
MPDZ-NF1B
|
rs1324183
|
A/C
|
A
|
0.25
|
0.28
|
0.4
|
0.8 (0.8-1.2)
|
|
RXRA-COL5A1
|
rs1536482
|
A/G
|
A
|
0.45
|
0.41
|
0.4
|
1.1 (0.8-1.6)
|
|
COL5A1
|
rs7044529
|
C/T
|
T
|
0.14
|
0.13
|
0.8
|
1.1 (0.7-1.7)
|
|
LCN12-PTGDS
|
rs11145951
|
C/T
|
T
|
0.44
|
0.49
|
0.2
|
0.8 (0.6-1.1)
|
|
FOXO1
|
rs2721051
|
C/T
|
T
|
0.14
|
0.11
|
0.2
|
1.4 (0.9-2.2)
|
|
BANP-ZNF49
|
rs9938149
|
A/C
|
C
|
0.29
|
0.32
|
0.4
|
0.9 (0.6-1.2)
|
- CCT Central cornea thickness; SNP single nucleotide polymorphism; KC keratoconus; A1/A2 Allele 1/Allele 2; MA minor allele; MAF minor allele frequency; p-value, derived from two-tailed fisher exact test; OR odds ratio; CI confidence interval. COL4A3 Collagen, type IV, alpha (Goodpasture antigen); FNDC3B fibronectin type III domain containing 3B; MPDZ multiple PDZ domain protein; NF1B neurofibromin 1b; COL5A1 collagen, type V, alpha 1; LCN12 lipocalin 12; PTGDS prostaglandin D2 synthase 21 kDa; FOXO1 forkhead box O1; BANP BTG3 associated nuclear protein; ZNF469 zinc finger protein 469
