Table 3 Activity of N-1 and 4-substituted piperidine analogs of the PIP series against M. tuberculosis and staphylococcus aureus
From: The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity
Compound | Structure | Mtb. MICa(μM) | % Ib | TC50c(μM) |
|---|---|---|---|---|
23 |
| >20 | <30 | 42 |
24 |
| >20 | <30 | 47 |
28 |
| >20 | <30 | 75 |
25 |
| >20 | <30 | >100 |
26 |
| >20 | <30 | >100 |
27 |
| >20 | <30 | 37 |
29 |
| >20 | 42 | 13 |
30 |
| >20 | <30 | >100 |
