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Table 3 Activity of N-1 and 4-substituted piperidine analogs of the PIP series against M. tuberculosis and staphylococcus aureus

From: The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity

Compound Structure Mtb. MICa(μM) % Ib TC50c(μM)
23 >20 <30 42
24 >20 <30 47
28 >20 <30 75
25 >20 <30 >100
26 >20 <30 >100
27 >20 <30 37
29 >20 42 13
30 >20 <30 >100
  1. aMtb. MIC is the minimum concentration required to inhibit growth of M. tuberculosis completely in liquid culture. MIC is the average of two independent experiments; b% inhibition of growth at 20 μM for compounds with MIC >20 μM. ND: not determined; cTC50 is the concentration required to inhibit growth of Vero cell line by 50%. TC50 is the average of two independent experiments.