Table 1 Activity of N-substituted analogs of the PIP series against M. tuberculosis
From: The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity
| |||||
|---|---|---|---|---|---|
Compound | R-group | Mtb. MICa(μM) | % Ib | TC50c(μM) | Staphylococcus aureus IC90(μM) |
1 |
| 10 | - | 28 | >200 |
2 | H | >20 | <30 | 14 | >200 |
3 |
| 20 | - | 1.8 | ND |
4 |
| >20 | <30 | 31 | ND |
5 |
| >20 | <30 | 21 | ND |
6 |
| >20 | 74 | 12.5 | ND |
7 |
| >20 | <30 | 71 | >200 |
8 |
| >20 | <30 | 66 | ND |
9 |
| >20 | <30 | 13 | ND |
10 |
| >20 | <30 | 80 | ND |
11 |
| >20 | <30 | >100 | ND |
