Figure 1
From: Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes
Schematic representation of RNAi vectors. (A) A typical RNAi transgene expressing long dsRNA hairpin under the control of oocyte-specific ZP3 promoter [5]. (B) A shRNA expressing cassette based on the endogenous human miR-30 precursor. (C) Highlighted features and adaptations of the pTMP plasmid to produce the expression cassette of the pZMP plasmid for transgenic RNAi in the oocyte.