Skip to main content

Table 1 Sciatic Nerve Conduction Studies in Hexb+/- and Hexb-/- Mice

From: Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

  Hexb+/- Hexb-/-
CNCV (m/s)a 23.6 ± 0.6 (8) 25.1 ± 0.9 (9)
  100 sec-1 400 sec-1 600 sec-1
Percent ΔCNCVa
   Hexb+/- 2% ± 1 (7) 20% ± 4 (L) (7) 18% ± 4 (L) (6)
   21% ± 4 (S) (7) 19% ± 3 (S) (6)
   Hexb-/- 5% ± 1 (9)* 20% ± 2 (L) (9) 22% ± 3 (L) (8)
   22% ± 2 (S) (9) 22% ± 4 (S) (8)
Wedensky Ratioa
   Hexb+/- 0.99 ± 0.00 (7) 0.67 ± 0.08 (7) 0.46 ± 0.09 (6)
   Hexb-/- 0.99 ± 0.00 (9) 0.84 ± 0.03 (9)* 0.58 ± 0.08 (8)
Amplitude Decrease Ratioa
   Hexb+/- - 0.54 ± 0.06 (L) (7) 0.41 ± 0.06 (L) (6)
   0.37 ± 0.06 (S) (7) 0.17 ± 0.02 (S) (6)
   Hexb-/- - 0.50 ± 0.03 (L) (9) 0.39 ± 0.03 (L) (8)
   0.42 ± 0.03 (S) (9) 0.22 ± 0.04 (S) (8)
  1. CNCV, compound nerve conduction velocity; Percent ΔCNCV, Wedensky Ratio, Amplitude Decrease Ratio, see Materials and Methods; L, S, see Figure 1
  2. a Values represent the mean ± SEM (n)
  3. * p < 0.05 (two-tailed, unpaired t-test), Hexb+/- vs. Hexb-/-
Back to article page

Journal of Negative Results in BioMedicine

ISSN: 1477-5751

Contact us