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Table 1 Sciatic Nerve Conduction Studies in Hexb+/- and Hexb-/- Mice

From: Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

 

Hexb+/-

Hexb-/-

CNCV (m/s)a

23.6 ± 0.6 (8)

25.1 ± 0.9 (9)

 

100 sec-1

400 sec-1

600 sec-1

Percent ΔCNCVa

   Hexb+/-

2% ± 1 (7)

20% ± 4 (L) (7)

18% ± 4 (L) (6)

  

21% ± 4 (S) (7)

19% ± 3 (S) (6)

   Hexb-/-

5% ± 1 (9)*

20% ± 2 (L) (9)

22% ± 3 (L) (8)

  

22% ± 2 (S) (9)

22% ± 4 (S) (8)

Wedensky Ratioa

   Hexb+/-

0.99 ± 0.00 (7)

0.67 ± 0.08 (7)

0.46 ± 0.09 (6)

   Hexb-/-

0.99 ± 0.00 (9)

0.84 ± 0.03 (9)*

0.58 ± 0.08 (8)

Amplitude Decrease Ratioa

   Hexb+/-

-

0.54 ± 0.06 (L) (7)

0.41 ± 0.06 (L) (6)

  

0.37 ± 0.06 (S) (7)

0.17 ± 0.02 (S) (6)

   Hexb-/-

-

0.50 ± 0.03 (L) (9)

0.39 ± 0.03 (L) (8)

  

0.42 ± 0.03 (S) (9)

0.22 ± 0.04 (S) (8)

  1. CNCV, compound nerve conduction velocity; Percent ΔCNCV, Wedensky Ratio, Amplitude Decrease Ratio, see Materials and Methods; L, S, see Figure 1
  2. a Values represent the mean ± SEM (n)
  3. * p < 0.05 (two-tailed, unpaired t-test), Hexb+/- vs. Hexb-/-