Figure 6
From: Searching for plasticity in dissociated cortical cultures on multi-electrode arrays
Results of Series III: Changes induced in specific responses by paired-pulse tetanization. A Changes induced by tetanization using protocols III.1 (left) and III.4 (right) in responses to electrodes S1, S2 and the control electrodes, compared to spontaneous drift. Plot symbols indicate stimulation electrode; key applies to both panels. Each point corresponds to one recording electrode in one of 8 experiments. All responses are averaged over 120 presentations of the stimulus. In protocol III.4 only, responses to electrodes S1, S2 were significantly affected by tetanization. B Summary of all experiments. Shown are mean and SEM across all electrode pairs in all experiments for a given protocol (N = 67, 67, 142, and 167 for protocols III.1, III.2, III.3, and III.4). Large bars for spontaneous changes in the panel for protocol III.1 indicate ongoing drift. Asterisks above bars for protocol III.4 mark significant differences between changes concomitant with tetanization and spontaneous changes: p < 0.001 (***), paired t-test. Asterisks below bars indicate significant differences between changes in responses to tetanized electrodes and control electrodes: p < 0.001 (***), unpaired t-test.