Polymorphisms within inflammatory genes and colorectal cancer

Table 1 Odd ratios and 95% confidence intervals (95% CI) for colorectal cancer by genotypes under investigation.

Gene and SNP	Controls N°	Cases N°	OR (95%CI)	P _codominant ¹	P _additive ²
TLR4 Asp299Gly
AA	232	251	1
AG	37	31	0.75(0.45–1.27)	0.29	0.29
GG	0	0	N.A.
CD14 -260 T>C
TT	63	68	1
TC	137	151	0.98(0.65–1.50)	0.82	0.58
CC	65	62	0.87(0.53–1.43)
MCP1 -2518 A>G
AA	138	161	1
AG	97	97	0.86(0.6–1.24)	0.71	0.46
GG	16	18	0.88(0.43–1.82)
IL12A +7506 A>T
AA	97	102	1
AT	108	136	1.19(0.81–1.74)	0.49	0.99
TT	41	37	0.90(0.53–1.53)
IL12A +8707 A>G
AA	75	69	1
AG	121	149	1.30(0.86–1.96)	0.25	0.87
GG	68	59	0.94(0.58–1.53)
IL12A +9177 T>A
TT	100	108	1
TA	121	140	1.04(0.72–1.51)	0.73	0.68
AA	43	39	0.85(0.51–1.43)
IL12A +9508 G>A
GG	104	106	1
GA	124	135	1.05(0.73–1.52)	0.85	0.85
AA	40	36	0.91(0.53–1.54)
NOS2A +524T>C
TT	93	92	1
CT	127	142	1.15(0.79–1.68)	0.76	0.56
CC	45	49	1.12(0.68–1.86)
TNF -857C>T
GG	220	219	1
GA	45	58	1.32(0.85–2.04)	0.41	0.19
AA	3	4	1.55(0.34–7.09)
PTGS1 V444I
GG	265	280	1
GA	5	3	0.52(0.12–2.22)	0.36	0.36
AA	0	0	N.A.

¹ P-value for the codominant model, comparing heterogeneity among three genotypes
² P-value for the log-additive model, comparing the effect of each additional variant allele

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