Figure 4

Promoter analysis human GP210 and homology to its mouse counterpart. A 500 bp sequence upstream of translation start site was analyzed for the presence of consensus transcription factor binding sites. Upper lane is the human sequence, and lower sequence is mouse. Homology in the (GT)n repeat between human and mouse genomic sequences and its position relative to the translation start codon. The translation start site is in bold and numbered +1. Homology to the mouse sequence is marked in grey, Outer gene specific primer (ogsp) and inner gene specific primer (igsp) used for transcription start definition using RLM-RACE are underlined with arrows. The transcription initiation sites are positioned with empty arrows and the start nucleotide is in bold. Putative transcription binding motifs are underlined. Some elements for different transcription factors overlap. Only sense strand binding sites were considered. Legend: Sp1, Simian-virus-40-protein 1; EGR2, Early growth response gene 2; WT1, Wilms' tumor zink finger protein 1; PuF, c-myc purine-binding transcription factor.