In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats

Table 5 ATPases and p -NPPases activities in the frontal cortex in the presence or absence of 1 mM of glutamatergic agonists

	K⁺- pNPPase (10 mM)	Mg²⁺-pNPPase (10 mM)	Na⁺,K⁺-ATPase (9 mM)	Mg²⁺-ATPase (9 mM)	Na⁺,K⁺-ATPase (2 mM)	Mg²⁺-ATPase (2 mM)
Control	169.6 ± 19.4	53.7 ± 3.3	289.4 ± 22.4	138.7 ± 14.7	173.0 ± 31.7	192.8 ± 22.3
Glutamate	167.2 ± 20.3	55.0 ± 3.1	255.2 ± 35.3	129.5 ± 5.8	162.4 ± 6.5	170.5 ± 24.8
Control	169.4 ± 8.9	53.4 ± 3.6	305.7 ± 22.1	159.5 ± 18.5	161.6 ± 10.9	188.4 ± 16.1
NMDA	168.5 ± 3.1	53.8 ± 2.4	275.3 ± 38.9	146.7 ± 7.1	157.5 ± 17.7	176.8 ± 12.3
Control	172.5 ± 11.2	41.7 ± 2.9	265.2 ± 36.4	202.4 ± 12.7	141.4 ± 15.9	165.5 ± 24.3
AMPA	174.2 ± 17.4	41.2 ± 1.8	304.0 ± 21	213.4 ± 17.7	136.7 ± 19.4	167.6 ± 12.1
Control	165.3 ± 18.5	57.6 ± 1.8	296.8 ± 46.9	205.8 ± 17.7	154.6 ± 13.4	166.7 ± 12.5
Kainate	179.9 ± 23.7	55.5 ± 6.9	257.8 ± 35.1	189.6 ± 13.4	149.3 ± 27.7	163.7 ± 11.6

Values are expressed as mean ± standard deviation (5 animals/group). ATPases activities are expressed in nmol of P_i/mg protein/min, and p-PNPPases activities are expressed in nmol of p-nitrophenol/mg protein/min. The concentrations of the substrates are shown in parentheses.

ISSN: 1477-5751