From: TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
TOPBP1 Genotype | OR (95% CI) (any Cys vs. Arg/Arg) | p | |||
---|---|---|---|---|---|
Arg/Arg | Arg/Cys | Cys/Cys | |||
Population controls (n = 1014) | 879 (.87) | 130 (.13) | 5 (.005) | ||
Breast cancer (n = 1064) | 936 (.88) | 123 (.12) | 5 (.005) | 0.89 (0.69-1.15) | 0.39 |
- familial | 150 (.88) | 19 (.11) | 1 (.01) | 0.87 (0.53-1.43) | 0.56 |
- bilateral | 118 (.93) | 9 (.07) | 0 | 0.49 (0.24- 0.99) | 0.047 |
- age < 50 ys | 263 (.89) | 31 (.10) | 2 (.01) | 0.82 (0.55-1.22) | 0.37 |
- ductal | 606 (.90) | 69 (.10) | 2 (.003) | 0.76 (0.56-1.04) | 0.09 |
- node positive | 270 (.88) | 36 (.12) | 1 (.01) | 0.89 (0.61-1.32) | 0.63 |
- ER negative | 72 (.87) | 10 (.12) | 1 (.01) | 0.99 (0.51-1.92) | 1 |