From: Searching for plasticity in dissociated cortical cultures on multi-electrode arrays
Ref. | Induction stimuli | Test stimuli | Results |
---|---|---|---|
Maeda et al. (1998) [24] | Trains of 20 pulses at 20 Hz simultaneously to each of 5 electrodes, repeated 5–10× at 10–15 s intervals. | Trains of 20–30 pulses at 1 kHz or stronger single pulses, to 1 or 5 electrodes, repeated every 15–30 s. | Increased probability of evoking array-wide bursts by test stimuli after tetanization. |
Jimbo et al. (1998) [25] | Trains of 11 pulses at 20 Hz to a single electrode, repeated 10× at 5 s intervals. | Single pulses, repeated every 10 s. | As above, plus earlier and more precisely timed onset for intracellular inward currents due to evoked bursts. |
Jimbo et al. (1999) [26] | Trains of 10 pulses at 20 Hz to one electrode, repeated 20× at 5 s intervals. | Individual pulses to each of 64 electrodes, repeated 10× at 3 s intervals. | 'Pathway- dependent' plasticity. |
Tateno and Jimbo (1999) [27] | As above, as well as simultaneous tetanization of a pair of electrodes. | Individual pulses to the tetanized electrodes, repeated 53×. | Increased response to test pulses after paired tetani, with improved temporal precision of first response spikes. |
Shahaf and Marom (2001) [3] | Bipolar stimulation between a pair of electrodes, at 1–3 s intervals, repeated until the desired response was seen, or for 10 min max. | Induction stimuli served as test stimuli. | Desired responses (increased spike rate 50–60 ms post-stimulus) obtained after fewer trials on successive test series. |
Ruaro et al. (2005) [5] | Trains of 100 pulses at 250 Hz simultaneously to each of 15 electrodes in an L-shape, repeated 40× at 2 s intervals. | Stimuli, simultaneously to several electrodes, in an L- or ⌉-shape. | Responses to L-shape enhanced relative to ⌉-shape. |