Figure 1From: Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure The effects of topoisomerase I inhibitors on T. cruzi epimastigotes after 72Â h of treatment. (a) Topotecan affected cell proliferation especially after using higher drug concentrations. (b) Cell viability of T. cruzi treated with topotecan was reduced in a dose-dependent way after treatment for 48Â h. (c) Irinotecan did not cause a significant growth inhibition even after treatment for 72Â h. The asterisks indicate drug addition to the culture medium. Data are the average of three independent experiments. DMSO, dimethyl sulfoxide.Back to article page