In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats

Table 1 ATPases and p -NPPases activities in the frontal cortex in the presence or absence of 50 μM of glutamatergic agonists

	K⁺- pNPPase (10 mM)	Mg²⁺-pNPPase (10 mM)	Na⁺,K⁺-ATPase (9 mM)	Mg²⁺-ATPase (9 mM)	Na⁺,K⁺-ATPase (2 mM)	Mg²⁺-ATPase (2 mM)
Control	149.7 ± 15.6	56.48 ± 4.2	280.4 ± 33.8	158.6 ± 22.8	129.5 ± 15.9	109.9 ± 7.4
Glutamate	146.6 ± 25.7	54.83 ± 4.2	299.7 ± 40.9	148.8 ± 26.2	125.6 ± 12.1	107.9 ± 11.2
Control	143 ± 8.5	48.24 ± 3.1	302.8 ± 33.3	139.3 ± 10.7	128.6 ± 25	61.93 ± 5.8
NMDA	148.1 ± 10.3	45.39 ± 3.3	274.7 ± 38.7	148.2 ± 11.8	134.4 ± 26.2	63.45 ± 5.8
Control	131.5 ± 6.5	49.74 ± 2.4	313.9 ± 51.6	178.2 ± 28.8	138.6 ± 24.6	70.42 ± 3.8
AMPA	139.1 ± 6.7	48.64 ± 4.7	325.9 ± 36.7	180 ± 14.3	146.8 ± 20.6	63.26 ± 8.7
Control	134.3 ± 10.5	47.64 ± 5.1	310.7 ± 69.7	147.7 ± 15.2	149.3 ± 13.2	81.58 ± 6.9
Kainate	142.9 ± 15.2	45.4 ± 5.1	319.7 ± 51.9	130.3 ± 13.4	144.6 ± 18.1	83.61 ± 9.8

Values are expressed as mean ± standard deviation (5 animals/group). ATPases activities are expressed in nmol of P_i/mg protein/min, and p-PNPPases activities are expressed in nmol of p-nitrophenol/mg protein/min. The concentrations of the substrates are shown in parentheses.

ISSN: 1477-5751