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  1. Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and ...

    Authors: Yun-Liang Yang, Ming-Fang Cheng, Ya-Wen Chang, Tzuu-Guang Young, Hsin Chi, Sai Cheong Lee, Bruno Man-Hon Cheung, Fan-Chen Tseng, Tun-Chieh Chen, Yu-Huai Ho, Zhi-Yuan Shi, Chung-Huang Hubert Chan, Ju-Yu Lin and Hsiu-Jung Lo
    Citation: Journal of Negative Results in BioMedicine 2008 7:12
  2. To determine the impact of pre-operative and intra-operative ilioinguinal and iliohypogastric nerve block on post-operative analgesic utilization and length of stay (LOS).

    Authors: Salim A Wehbe, Labib M Ghulmiyyah, El-Khawand H Dominique, Sarah L Hosford, Carole M Ehleben, Steven L Saltzman and Eric Scott Sills
    Citation: Journal of Negative Results in BioMedicine 2008 7:11
  3. Obstructive sleep apnea syndrome (OSAS) is a recognized risk factor for cardiovascular morbidity and mortality, perhaps due to causative exacerbations of systemic oxidative stress. Putative oxidative stress re...

    Authors: Izabela Grabska-Kobylecka, Andrzej Kobylecki, Piotr Bialasiewicz, Maciej Krol, Golsa Ehteshamirad, Marek Kasielski and Dariusz Nowak
    Citation: Journal of Negative Results in BioMedicine 2008 7:10
  4. Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Huma...

    Authors: Qumar Parwez, Susanne Stemmler, Jörg T Epplen and Sabine Hoffjan
    Citation: Journal of Negative Results in BioMedicine 2008 7:9
  5. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an important downregulatory molecule expressed on both T and B lymphocytes. Numerous population genetics studies have documented significant associations between au...

    Authors: Andrew Berry, Matt Tector and Martin K Oaks
    Citation: Journal of Negative Results in BioMedicine 2008 7:8
  6. A number of studies has addressed the possible association between patent foramen ovale (PFO) and stroke. However, the role of PFO in the pathogenesis of cerebral ischemia has remained controversial and most s...

    Authors: Holger Poppert, Melanie Morschhaeuser, Regina Feurer, Angelina Bockelbrink, Jens Schwarze, Lorena Esposito, Peter Heider, Dirk Sander and Bernhard Hemmer
    Citation: Journal of Negative Results in BioMedicine 2008 7:7
  7. The aim of the present study was to assess accommodation as a possible indicator of changes in the autonomic balance caused by altered cognitive demand. Accounting for accommodative responses from a human fact...

    Authors: Stephanie Jainta, Joerg Hoormann and Wolfgang Jaschinski
    Citation: Journal of Negative Results in BioMedicine 2008 7:6
  8. Several mutations in the PALB2 gene (partner and localizer of BRCA2) have been associated with an increased risk of breast cancer, including a founder mutation, 1592delT, reported in Finnish breast cancer familie...

    Authors: Haukur Gunnarsson, Adalgeir Arason, Elizabeth M Gillanders, Bjarni A Agnarsson, Gudrun Johannesdottir, Oskar Th Johannsson and Rosa B Barkardottir
    Citation: Journal of Negative Results in BioMedicine 2008 7:5
  9. The Fischer 344/NHsd rat undergoes age-related, progressive, high-frequency hearing loss beginning at age 12 months. The loss has been linked to defects/death in the outer hair cells related to oxidative stres...

    Authors: Eric C Bielefeld, Donald Coling, Guang-Di Chen and Donald Henderson
    Citation: Journal of Negative Results in BioMedicine 2008 7:4
  10. It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our labora...

    Authors: Susanne Brummelte, Thorsten Grund, Gunther H Moll, Gertraud Teuchert-Noodt and Ralph R Dawirs
    Citation: Journal of Negative Results in BioMedicine 2008 7:2
  11. The aim of this study was to compare body composition results from bioelectrical spectroscopy (BIS) with results from dual energy X-ray absorptiometry (DXA) in a population of male elite athletes. Body composi...

    Authors: Ulla Svantesson, Martina Zander, Sofia Klingberg and Frode Slinde
    Citation: Journal of Negative Results in BioMedicine 2008 7:1
  12. Matrix metalloproteinases (MMPs) are proteolytic enzymes that may contribute to tissue destruction in Sjögren's syndrome (SS). Low-dose doxycycline (LDD) inhibits MMPs. We evaluated the efficacy of LDD for the...

    Authors: Hubertus Seitsalo, Raija K Niemelä, Magdalena Marinescu-Gava, Tuija Vuotila, Leo Tjäderhane and Tuula Salo
    Citation: Journal of Negative Results in BioMedicine 2007 6:11
  13. A disturbance in the immune system has been described in Turner syndrome (45,X), with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune disease...

    Authors: Annika E Stenberg, Lisskulla Sylvén, Håkan Hedstrand, Olle Kämpe and Malou Hultcrantz
    Citation: Journal of Negative Results in BioMedicine 2007 6:10
  14. The matrix metalloproteinases (MMPs) are enzymes that cleave various components of the extracellular matrix (ECM) and basement membranes. MMPs are expressed in melanocytes and their overexpression has been lin...

    Authors: Javier Cotignola, Pampa Roy, Ami Patel, Nicole Ishill, Shivang Shah, Alan Houghton, Daniel Coit, Allan Halpern, Klaus Busam, Marianne Berwick and Irene Orlow
    Citation: Journal of Negative Results in BioMedicine 2007 6:9
  15. Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb gene) of β-hexosaminidase A (αβ) and B (ββ). The β-subunit together with the GM2 activator prote...

    Authors: Melanie A McNally, Rena C Baek, Robin L Avila, Thomas N Seyfried, Gary R Strichartz and Daniel A Kirschner
    Citation: Journal of Negative Results in BioMedicine 2007 6:8
  16. We investigated the association of developmental dysplasia of the hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu...

    Authors: Birender Kapoor, Colin Dunlop, Charles Wynn-Jones, Anthony A Fryer, Richard C Strange and Nicola Maffulli
    Citation: Journal of Negative Results in BioMedicine 2007 6:7
  17. Pluripotent embryonal carcinomas are good potential models, to study, "in vitro," the mechanisms that control differentiation during embryogenesis. The NTERA2cl.D1 (NT2/D1) cell line is a well known system of ect...

    Authors: Pedro D Simões and Teresa Ramos
    Citation: Journal of Negative Results in BioMedicine 2007 6:5
  18. Temporomandibular disorders (TMDs) are by far the most predominant condition affecting the temporomandibular joint (TMJ), however many patients have mild self-limiting symptoms and should not be referred for s...

    Authors: Waseem Jerjes, Geir Madland, Charlotte Feinmann, Mohammed El Maaytah, Mahesh Kumar, Colin Hopper, Tahwinder Upile and Stanton Newman
    Citation: Journal of Negative Results in BioMedicine 2007 6:4
  19. Falls amongst elderly people are often associated with fractures. Training of balance and physical performance can reduce fall risk; however, it remains a challenge to identify individuals at increased risk of...

    Authors: Uffe Laessoe, Hans C Hoeck, Ole Simonsen, Thomas Sinkjaer and Michael Voigt
    Citation: Journal of Negative Results in BioMedicine 2007 6:2
  20. We developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone (TSH). Male derived bone marrow cells were transplanted to asses their effe...

    Authors: Gustavo E Guajardo-Salinas, Juan A Carvajal, Ángel A Gaytan-Ramos, Luis Arroyo, Alberto G López-Reyes, José F Islas, Beiman G Cano, Netzahualcoyótl Arroyo-Currás, Alfredo Dávalos, Gloria Madrid and Jorge E Moreno-Cuevas
    Citation: Journal of Negative Results in BioMedicine 2007 6:1
  21. Generalized progressive retinal atrophy (gPRA) is a hereditary ocular disorder with progressive photoreceptor degeneration in dogs. Four retina-specific genes, ATP binding cassette transporter retina (ABCA 4), co...

    Authors: Tanja Lippmann, Sandra M Pasternack, Britta Kraczyk, Sabine E Dudek and Gabriele Dekomien
    Citation: Journal of Negative Results in BioMedicine 2006 5:19
  22. Reduced growth during infancy is associated with adult insulin resistance. In a UK Caucasian cohort, the CSH1.01 microsatellite polymorphism in the growth hormone-chorionic somatomammotropin hormone gene cluster ...

    Authors: Rachel M Freathy, Simon MS Mitchell, Beatrice Knight, Beverley Shields, Michael N Weedon, Andrew T Hattersley and Timothy M Frayling
    Citation: Journal of Negative Results in BioMedicine 2006 5:18
  23. The World Health Organisation Study Group on Tobacco Product Regulation (TobReg) has issued in 2005 an "Advisory Note" entitled: "Waterpipe Tobacco Smoking: Health Effects, Research Needs and Recommended Actions ...

    Authors: Kamal Chaouachi
    Citation: Journal of Negative Results in BioMedicine 2006 5:17
  24. We attempted to induce functional plasticity in dense cultures of cortical cells using stimulation through extracellular electrodes embedded in the culture dish substrate (multi-electrode arrays, or MEAs). We ...

    Authors: Daniel A Wagenaar, Jerome Pine and Steve M Potter
    Citation: Journal of Negative Results in BioMedicine 2006 5:16

    The Erratum to this article has been published in Journal of Negative Results in BioMedicine 2007 6:3

  25. Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs...

    Authors: Stefano Landi, Federica Gemignani, Fabio Bottari, Lydie Gioia-Patricola, Elisabet Guino, María Cambray, Sebastiano Biondo, Gabriel Capella, Laura Boldrini, Federico Canzian and Victor Moreno
    Citation: Journal of Negative Results in BioMedicine 2006 5:15
  26. The mechanisms by which glucocorticoid therapy promotes obesity and insulin resistance are incompletely characterized. Modulations of the metabolically active hormones, tumour necrosis factor alpha (TNF alpha)...

    Authors: Jeetesh V Patel, David E Cummings, John P Girod, Alwin V Mascarenhas, Elizabeth A Hughes, Manjula Gupta, Gregory YH Lip, Sethu Reddy and Daniel J Brotman
    Citation: Journal of Negative Results in BioMedicine 2006 5:14
  27. Dupuytren's contracture or disease (DD) is a fibro-proliferative disease of the hand that results in finger flexion contractures. Increased cellular β-catenin levels have been identified as characteristic of t...

    Authors: David B O'Gorman, Yan Wu, Shannon Seney, Rebecca D Zhu and Bing Siang Gan
    Citation: Journal of Negative Results in BioMedicine 2006 5:13
  28. The ratio of index finger to ring finger length (2D:4D index) may be an indicator of gonadal hormone exposure, because the differentiation of gonads, fingers and toes is influenced by the same HOXA and HOHD ge...

    Authors: Tapio Vehmas, Svetlana Solovieva and Päivi Leino-Arjas
    Citation: Journal of Negative Results in BioMedicine 2006 5:12
  29. Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) ...

    Authors: Martin O Weickert, Manja Reimann, Bärbel Otto, Wendy L Hall, Katherina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M Williams, Hans-Joachim Zunft and Corinna Koebnick
    Citation: Journal of Negative Results in BioMedicine 2006 5:11
  30. Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and...

    Authors: Aline Meirhaeghe, Séverine Thomas, Frédéric Ancot, Dominique Cottel, Dominique Arveiler, Jean Ferrières and Philippe Amouyel
    Citation: Journal of Negative Results in BioMedicine 2006 5:10
  31. Experimental studies demonstrate that infection with trypanosoma cruzi causes vasculitis. The inflammatory lesion process could hypothetically lead to decreased distensibility of large and small arteries in advan...

    Authors: Humberto Villacorta, Luiz Aparecido Bortolotto, Edmundo Arteaga and Charles Mady
    Citation: Journal of Negative Results in BioMedicine 2006 5:9
  32. Vascular endothelial growth factor (VEGF) and endostatin are angiogenic and anti-angiogenic molecules, respectively, that have been implicated in neurogenesis and neuronal survival. Using alkaline phosphatase ...

    Authors: Ingrid Berger, Sonja Stahl, Natalia Rychkova and Ute Felbor
    Citation: Journal of Negative Results in BioMedicine 2006 5:8
  33. Mutations in the Cu/Zn superoxide dismutase (Sod1) gene have been reported to cause adult-onset autosomal dominant Amyotrophic Lateral Sclerosis (FALS). In sporadic cases (SALS) de novo mutations in the Sod1 gene...

    Authors: Francesca Luisa Conforti, Teresa Sprovieri, Rosalucia Mazzei, Carmine Ungaro, Alessandro Tessitore, Gioacchino Tedeschi, Alessandra Patitucci, Angela Magariello, AnnaLia Gabriele, Vincenzo Labella, Isabella Laura Simone, Giovanni Majorana, Maria Rosaria Monsurrò, Paola Valentino, Maria Muglia and Aldo Quattrone
    Citation: Journal of Negative Results in BioMedicine 2006 5:7
  34. Aortic baroreceptors (BRs) comprise a class of cranial afferents arising from major arteries closest to the heart whose axons form the aortic depressor nerve. BRs are mechanoreceptors that are largely devoted ...

    Authors: Patrick J Reynolds, Wei Fan and Michael C Andresen
    Citation: Journal of Negative Results in BioMedicine 2006 5:6
  35. Susceptibility to infection by bacterium such as Bacillus anthracis has a genetic basis in mice and may also have a genetic basis in humans. In the limited human cases of inhalation anthrax, studies suggest that ...

    Authors: Pauline L Lee, Carol West, Karen Crain and Lei Wang
    Citation: Journal of Negative Results in BioMedicine 2006 5:5
  36. The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the s...

    Authors: Agnès Burel, Thomas Mouchel, Sylvie Odent, Filiz Tiker, Bertrand Knebelmann, Isabelle Pellerin and Daniel Guerrier
    Citation: Journal of Negative Results in BioMedicine 2006 5:4
  37. There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to β-amyloid dep...

    Authors: I Manna, P Valentino, A La Russa, F Condino, R Nisticò, M Liguori, A Clodomiro, V Andreoli, D Pirritano, R Cittadella and A Quattrone
    Citation: Journal of Negative Results in BioMedicine 2006 5:3
  38. Autonomic disturbances in tetanus are traditionally associated with adrenergic variations and/or cardiac dysfunction, based on case report data. The objective of this study was to measure catecholamines, (TNF)...

    Authors: Janete S Brauner and Nadine Clausell
    Citation: Journal of Negative Results in BioMedicine 2006 5:2
  39. The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime...

    Authors: Daniel Guerrier, Thomas Mouchel, Laurent Pasquier and Isabelle Pellerin
    Citation: Journal of Negative Results in BioMedicine 2006 5:1
  40. Huntington disease (HD) is a fully penetrant, autosomal dominantly inherited disorder associated with abnormal expansions of a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of repeat ...

    Authors: Wiebke Hansen, Carsten Saft, Jürgen Andrich, Thomas Müller, Stefan Wieczorek, Jörg T Epplen and Larissa Arning
    Citation: Journal of Negative Results in BioMedicine 2005 4:12
  41. Cortactin, an actin binding protein, has been associated with Sertoli cell ectoplasmic specializations in vivo, based on its immunolocalization around the heads of elongated spermatids, but not previously identif...

    Authors: Katja M Wolski, Edward Haller and Don F Cameron
    Citation: Journal of Negative Results in BioMedicine 2005 4:11
  42. Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recently, mutations in the PINK1 (PARK6) gene were shown to rarely cause autosomal-recessively transmitted, early-onset parkinsonism....

    Authors: Anna Melissa Schlitter, Martin Kurz, Jan P Larsen, Dirk Woitalla, Thomas Mueller, Joerg T Epplen and Gabriele Dekomien
    Citation: Journal of Negative Results in BioMedicine 2005 4:10
  43. Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defens...

    Authors: Edward J Hollox, Jane Davies, Uta Griesenbach, Juliana Burgess, Eric WFW Alton and John AL Armour
    Citation: Journal of Negative Results in BioMedicine 2005 4:9
  44. Crohn's disease (CD) presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood, there is ...

    Authors: Sonja EN Wagenleiter, Peter Jagiello, Denis A Akkad, Larissa Arning, Thomas Griga, Wolfram Klein and Jörg T Epplen
    Citation: Journal of Negative Results in BioMedicine 2005 4:8
  45. Apoptosis, the programmed death of cells, plays a distinct role in the etiopathogenesis of Multiple sclerosis (MS), a common disease of the central nervous system with complex genetic background. Yet, it is no...

    Authors: René Gödde, Stefanie Brune, Peter Jagiello, Eckhart Sindern, Michael Haupts, Sebastian Schimrigk, Norbert Müller and Jörg T Epplen
    Citation: Journal of Negative Results in BioMedicine 2005 4:7
  46. Obesity shows an increasing prevalence worldwide and a decrease in energy expenditure has been suggested to be one of the risk factors for developing obesity. An increase in resting energy expenditure would ha...

    Authors: Ebba Carlsson, Hannah Helgegren and Frode Slinde
    Citation: Journal of Negative Results in BioMedicine 2005 4:6