Table 3 Bioequivalence comparison of three drugs described by their name (overt) or as placebo (covert)
From: Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs
Drug name | Cephalexin | Ibuprofen | Paracetamol |
|---|---|---|---|
AUCT | |||
 PE (CI) | 98.47% (95.04–102.02) | 96.66% (91.79–101.79) | 100.62% (98.77–102.50) |
 MSR | 0.011 | 0.014 | 0.003 |
 CV | 10.5% | 11.9% | 5.5% |
AUCI | |||
 PE (CI) | 98.54% (95.34–101.83) | 99.96% (96.30–103.76) | 100.56% (98.71–102.45) |
 MSR | 0.009 | 0.007 | 0.003 |
 CV | 9.5% | 8.4% | 5.5% |
Cmax | |||
 PE (CI) | 97.87% (89.81–106.65) | 87.11% (76.66–98.99) | 106.79% (98.84–115.37) |
 MSR | 0.063 | 0.085 | 0.052 |
 CV | 25.5% | 29.8% | 23.1% |
AUCOverttmax | |||
 PE (CI) | 96.64% (82.17–113.66) | 64.44% (45.32–91.62) | 71.36% (51.45–98.96) |
 MSR | 0.224 | 0.642 | 0.931 |
 CV | 50.1% | 94.9% | 124.0% |
Cmax/AUCI | |||
 PE (CI) | 99.32% (93.00–106.08) | 87.15% (77.19–98.39) | 106.19% (99.15–113.73) |
 MSR | 0.037 | 0.076 | 0.041 |
 CV | 19.4% | 28.1% | 20.5% |