Table 1 Main characteristics of three randomized, 2-period, 2-sequence, cross-over studies comparing three drugs described by their name or as placebo
From: Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs
Drug name (dose) | Cephalexin (500Â mg) | Ibuprofen (400Â mg) | Paracetamol (500Â mg) |
|---|---|---|---|
Participants, No. (sex) | 41 (M), 9 (F) | 27 (M), 3 (F) | 47 (M), 3 (F) |
Age, mean (SD), year | 30.8 (6.2) | 31.4 (6.6) | 31.2 (5.4) |
BMI, mean (SD), kg/m2 | 24.8 (3.1) | 25.0 (4.2) | 25.2 (3.1) |
Adverse events (No.)a | Near fainting (1) | None | Localized rash (1) |
Washout period, hour | 24 | 24 | 48 |
Sampling frame, hour | 6 | 10 | 14 |
Assay range, μg/ml | 0.50–120 | 0.25–60 | 0.10–40 |