Table 1 Epitopes and cross reactivities of selected antibodies raised against Aβ

4G8

Raised against synthetic peptide Aβ17-24; epitope lies within aa 18–23; recognises multiple forms of Aβ

Cross reacts with APP770 and P3; reacts with conformational epitope of aggregated fibrils including α-synuclein

[29, 38, 39]

6E10

Raised against Aβ1-17; epitope lies within aa 4–9; recognises Aβ with intact N-terminal epitope

Cross reacts with APP and Aβ (1–16); No reaction predicted with P3

[3, 29]

6F3D

Raised against synthetic peptide Aβ8-17; epitope lies within aa 10–15; recognises Aβ with intact N-terminal epitope

Predicted to react with Aβ (1–16); Does not react with P3

[29, 31]

MBC40 (Aβ40)

Recognises C-terminal Aβ peptides ending at aa40; epitope not well described

Cross reacts with N-terminal truncated peptides including P3

[29]

MBC42 (Aβ42)

Recognises C-terminal Aβ peptides ending at aa42; epitope not well described

Cross reacts with N-terminal truncated peptides including P3

[29]

BS85

Raised against Aβ (25–35); recognises Aβ38, Aβ39, Aβ40, Aβ42 and Aβ43; epitope not well described

Cross reacts with N-terminal truncated peptides including P3

[28]

BC05

Raised against Aβ (35–43); recognises Aβ42 and Aβ43; epitope not well described

Cross reacts with N-terminal truncated peptides including P3; does not recognise Aβ40; used in commercial ELISA kits for the detection of Aβ42

[28, 44]

BA27

Raised against Aβ (1–40) Recognises Aβ40; 100-1000x more reactive with Aβ40 than Aβ42 and Aβ43; epitope not well described

Cross reacts with N-terminal truncated peptides including P3; used in commercial ELISA kits for the detection of Aβ40

[28]

AβN17 (Leu)

Raised against P3 (40); recognises P3 (40) and synthetic P3 (42) peptide; epitope not well described

Reactivity with insoluble, aggregated P3 (42) not confirmed

[28, 42, 57]

3D6

Raised against Aβ with N-terminal aspartic acid; epitope not well described

Does not cross react with sAPPs or full length APP; No reaction predicted with P3; parent of Bapineuzumab; epitope not well described

[53]

Raised against Aβ (13–28); epitope not well described

Solanezumab

[53]