Fig. 2
From: Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer’s disease
In situ hybridization of transgenic (a-f) and wild-type APP/PS1 mouse brains (g-i) at the age of 12 months. Plaque staining is obtained exclusively in transgenic hippocampal formation with sense (e; f; h; i) and antisense (b; c) probes for Cdh11 and Pcdh10. Amyloid beta immunohistochemistry confirmed the large number of plaques in the transgenic sections (d) with no staining visible in wild-type sections (g). The Nissl staining in (a) indicates a normal hippocampal cytoarchitecture in the transgenic brains. as, antisense probe; CA1-3, subdivision 1–3 of the cornu ammonis; DG, dentate gyrus; s, sense probe; tg, transgenic; wt, wild-type. Scale bar in i = 1 mm (applies to all panels)