Fig. 1
From: Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer’s disease
Nissl staining (a; f; k; p) and in situ hybridization of (proto-)cadherins in 12-months-old APP/PS1 wild-type mice (a-e) and transgenic mice (f-j), as well as in 18.5-months-old APP23 wild-type mice (k-o) and transgenic mice (p-t). Nissl staining revealed no differences in cytoarchitecture between the wild-type brains (a; k) and the transgenic brains (f; p). Transgenic brains only (g-j; q-t) showed staining of plaques by in situ hybridization in both mouse lines, whereas the overall endogenous expression patterns were similar to that of wild-type brains. The asterisks in b; d; j; k; n; o; p; q; r; s; t indicate artifacts that were induced during dissection of the brains (tissue tears) or collection of the sections on the glass slides (folds and bubbles). Amy, amygdala; Cx, cerebral cortex; Hip, hippocampus; LV, lateral ventricle; tg, transgenic; Th, thalamus; wt, wild-type. Scale bar in t = 1 mm (applies to all panels)