Fig. 1

Linkage disequilibrium plot between LRP5 SNPs showing region the rs3736228 and rs2306862 located using HapMap populations determined by Haploview 4.2 program. Each black triangle depicts haplotype blocks. LD is reported as D’. Bright red represents D’ = 1 and LOD ≥ 2, blue represents D’ = 1 and LOD < 2, pink represents D’ < 1, and LOD ≥ 2, and white represents D’ < 1 and LOD < 2. The r ² values are shown in blocks. The rs3736228 and rs2306862 are indicated by boxes. CHB, Han Chinese in Beijing, China; JPT, Japanese in Tokyo, Japan