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Table 4 mRNA and protein expression of pro-inflammatory cytokines 3 days after aortic constriction in male wild type and Tlr2 deficient mice

From: Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload

 

WT sham

WT TAC

Tlr2−/− sham

Tlr2−/− TAC

TNFα

1.00 ± 0.10

1.45 ± 0.15

0.90 ± 0.14

1.21 ± 0.26

IL-1β

1.00 ± 0.28

2.21 ± 0.52

1.19 ± 0.42

1.43 ± 0.21

IL-6

1.00 ± 0.24

5.33 ± 0.97

0.65 ± 0.12

5.74 ± 1.13*

IL-1β protein

1.46 ± 0.25

3.03 ± 0.53

1.53 ± 0.19

2.65 ± 0.44

IL-6 protein

15.84 ± 3.81

19.94 ± 3.68

13.14 ± 2.31

22.42 ± 2.63

  1. mRNA values are normalized to the respective sham group. Protein amount in pg/mg protein. Mean ± SEM, n = 3–4/sham group, n = 5–8/TAC group
  2. *indicates significant difference to respective sham group (p < 0.05, One-way ANOVA with Sidak post-hoc testing)
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Journal of Negative Results in BioMedicine

ISSN: 1477-5751

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