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Table 1 mRNA expression profiles of extracellular matrix related genes 14 days after aortic constriction in male wild type and Tlr2 deficient mice

From: Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload

 

WT sham

WT TAC

Tlr2−/− sham

Tlr2−/− TAC

Col1α1

1.00 ± 0.18

2.91 ± 0.43a

4.06 ± 0.67b

2.44 ± 0.35

Col3α1

1.00 ± 0.19

3.46 ± 0.46a

0.91 ± 0.10

2.52 ± 0.30c

Col4α1

1.00 ± 0.07

1.74 ± 0.21

1.26 ± 0.07

2.62 ± 0.44c

Biglycan

1.00 ± 0.06

1.91 ± 0.19a

0.88 ± 0.11

1.82 ± 0.18c

Decorin

1.00 ± 0.04

1.12 ± 0.06

0.90 ± 0.08

1.11 ± 0.09

Elastin

1.00 ± 0.32

2.94 ± 0.41a

0.69 ± 0.09

1.81 ± 0.22c,d

LOX

1.00 ± 0.25

2.96 ± 0.46a

0.84 ± 0.10

2.20 ± 0.37c

MMP2

1.00 ± 0.12

2.08 ± 0.36a

1.40 ± 0.19

1.73 ± 0.25

MMP9

1.00 ± 0.13

1.12 ± 0.15

1.08 ± 0.14

1.41 ± 0.17

MMP13

1.00 ± 0.09

1.68 ± 0.20a

1.42 ± 0.15

1.75 ± 0.17

  1. Values are normalized to wild type sham group, mean ± SEM, n = 8/group. Significant differences (p < 0.05, One-way ANOVA with Sidak post-hoc testing) between relevant groups are indicated by identical superscripted letters
  2. aWT sham vs. WT TAC
  3. bWT sham vs. Tlr2−/−
  4. cTlr2−/−sham vs. Tlr2−/− TAC
  5. dWT TAC vs. Tlr2−/− TAC