Fig. 1

Fourteen days of aortic constriction differentially modify biometric and hemodynamic measurements in male Tlr2 ^+/+ and Tlr2 ^−/− mice. a-c Heart weight (HW), left ventricular (LVW) and lung weight (LW) were normalized to tibia lengths (TL). Ratios increased in all TAC groups in comparison to sham groups. Tlr2 ^−/− mice developed a significantly elevated HW/TL ratio compared to Tlr2 ^+/+ mice (mean ± SEM, n = 5–11/group). d-h TAC altered left ventricular systolic pressure (LVSP), contraction (dP/dt_max) and relaxation (dP/dt_min) velocity in both genotypes, but changed left ventricular end-diastolic pressure (LVEDP) and heart rate (HR) in Tlr2 ^−/− mice only (mean ± SEM, One-way ANOVA with Sidak post-hoc testing, n = 9–12/group)