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Fig. 2 | Journal of Negative Results in BioMedicine

Fig. 2

From: ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model

Fig. 2

Syngeneic mammary tumor cell line 4 T1 subcutaneously transplanted growth. a The endogenous ADAMTS-18 expression in cultured 4 T1 cells (upper panel) or in xenograft 4 T1 tumors (lower panel). MEF, mouse embryonic fibroblast; bp, base pair; MW, molecular weight; **indicates P < 0.01. b Mice were challenged with 106 4 T1 cells, and tumor volumes were monitored for six weeks. c Survival rate of mice; (d) Final tumor weight in different genotype of mice. Adamts-18 +/+, wildtype mice; Adamts-18 -/-, knockout mice. e CD31 (40 × magnification) positive microvessels in each group (n = 5/group). Data are expressed as mean ± SD

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