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Fig. 1 | Journal of Negative Results in BioMedicine

Fig. 1

From: ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model

Fig. 1

Generation and characterization of Adamts-18 knockout mice with BALB/c background. a The mating strategy for producing BALB/c inbred Adamts-18 knockout mice; (b) PCR genotyping of wildtype (WT), heterozygote (HT), and knockout (KO) mice; (c) Western blot analysis of Adamts-18 in kidney, liver, and brain from different mice, β-actin was used as a loading control. WT, wild-type mouse; KO, knockout mouse. d Incidence rate of breast cancer in different generation of mice with BALB/C background; (e) Bearing-tumor mice number in the seventh generation of BALB/c inbred mice after orthotopically implanted within the mammary fat pad of mice with different dose of 4 T1 cells. f Representative photograph of breast tumor. Arrow refers to breast tumor; (g) Representative HE staining, bar = 50 μm

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