Characteristic | rs361525 + ve (AG/AA) | rs361525 -ve (GG) | P value (2- tailed) | |
---|---|---|---|---|
N | 9 | 9 | ||
(8 AG/1 AA) | ||||
Presence of COPD | 9/9 | 9/9 | ||
Age in years | 51 (50–65) | 60 (49–61) | 0.8 | |
Male | 7 (77.8) | 7 (77.8) | ||
AATD level (micromolar) | 3.8 (0.4) | 4.0 (0.5) | 0.8 | |
BMI | 21.2 (21.0–23.8) | 23.2 (22.0–26.0) | 0.3 | |
Smoking hx | Current | 1 | 0 | |
Ex/never | 7/1 | 8/1 | ||
Pack years | 22 (10–28) | 22 (9–30) | 0.9 | |
FEV1 (L) | 1.4 (0.1) | 1.4 (0.2) | 0.8 | |
FEV1 % predicted | 37.7 (33.4–43.4) | 33.6 (32.6–54.6) | 0.9 | |
FEV1/FVC ratio (%) | 32.0 (28.0–34.0) | 32.2 (23.0–33.0) | 0.5 | |
KCO % predicted | 53.9 (4.6) | 52.0 (4.8) | 0.8 | |
Emphysema on HRCT | 8/9 | 9/9 | ||
Chronic bronchitis phenotype | 4/9 | 5/9 | ||
Bronchiectasis on HRCT | 4/9 | 5/9 | ||
Inhaled steroids | 8/9 | 9/9 | ||
Median exacerbations per year | 1.0 (1.0–2.0) | 0.5 (0–1.0) | 0.3 |