MicroRNAs in urine are not biomarkers of multiple myeloma

Table 2 Validated microRNAs

miRNA	HD	MM	RCC	P value
	mean	mean	mean	P value
	(25–75)	(25–75)	(25–75)	HD vs. MM	RCC vs. MM	HD vs. RCC vs. MM
	Std. deviation	Std. deviation	Std. deviation	HD vs. MM	RCC vs. MM	HD vs. RCC vs. MM
miR-29a	−1.007	−0.984	−0.833	0.863	0.466	0.739
	(−1.145) - (−0.556)	(−1.384) - (−0.715)	(−1.172) - (−0.475)
	0.559	0.506	0.393
miR-29b	−2.204	−2.248	−2.064	0.570	0.394	0.581
	(−2.458) - (−1.751)	(−2.598) - (−1.848)	(−2.352) - (−1.493)
	0.446	0.580	0.438
miR-29c	−1.386	−1.426	−1.252	0.663	0.329	0.565
	(−1.656) - (−0.933)	(−1.796) - (−1.040)	(−1.570) - (−0.856)
	0.482	0.518	0.361
miR-25	−2.224	−2.106	−2.347	0.692	0.329	0.608
	(−2.593) - (−1.848)	(−2.595) - (−1.717)	(−2.742) - (−2.049)
	0.598	0.634	0.567
miR-22	−2.532	−2.247	−2.310	0.090	0.790	0.225
	(−2.954) - (−2.084)	(−2.744) - (−1.782)	(−2.566) - (−1.676)
	0.538	0.689	0.536
miR-106b	−1.788	−1.765	−1.612	0.958	0.496	0.776
	(−2.120) - (−1.419)	(−2.138) - (−1.423)	(−1.901) - (−1.102)
	0.460	0.555	0.524
miR-18a	−2.736	−2.824	−3.416	0.763	0.528	0.802
	(−4.359) - (0.000)	(−4.171) - (0.000)	(−4.303) - (−3.437)
	2.101	1.874	1.563
miR-200c	−0.909	−0.990	−0.645	0.543	0.088	0.237
	(−1.273) - (−0.449)	(−1.405) - (−0.588)	(−0.963) - (−0.487)
	0.610	0.595	0.374

Expression levels defined as logarithmic values of 2^-ΔCt normalized to cel-miR-39 expression levels as mean value and interquantile range with standard deviation. Nonparametric Kruskal-Wallis or Mann–Whitney U test was used to compare the values

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