Table 2 Activity of piperidine analogs with a carbonyl group of the PIP series against M. tuberculosis
From: The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity
| |||||
|---|---|---|---|---|---|
Compound | R-group | Mtb. MICa(μM) | % Ib | TC50c(μM) | Staphylococcus aureus IC90(μM) |
12 |
| >20 | <30 | >100 | >200 |
13 |
| >20 | <30 | >100 | >200 |
14 |
| >20 | <30 | 41 | ND |
15 |
| >20 | <30 | >100 | >200 |
16 |
| >20 | <30 | 22 | >200 |
17 |
| >20 | <30 | ND | ND |
18 |
| >20 | <30 | >100 | >200 |
19 |
| >20 | <30 | 68 | >200 |
20 |
| >20 | <30 | >100 | >200 |
21 |
| >20 | <30 | >100 | >200 |
22 |
| >20 | <30 | >100 | >200 |
