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Table 2 Activity of piperidine analogs with a carbonyl group of the PIP series against M. tuberculosis

From: The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity

Compound R-group Mtb. MICa(μM) % Ib TC50c(μM) Staphylococcus aureus IC90(μM)
12 >20 <30 >100 >200
13 >20 <30 >100 >200
14 >20 <30 41 ND
15 >20 <30 >100 >200
16 >20 <30 22 >200
17 >20 <30 ND ND
18 >20 <30 >100 >200
19 >20 <30 68 >200
20 >20 <30 >100 >200
21 >20 <30 >100 >200
22 >20 <30 >100 >200
  1. aMtb. MIC is the minimum concentration required to inhibit growth of M. tuberculosis completely in liquid culture. MIC is the average of two independent experiments; b% inhibition of growth at 20 μM for compounds with MIC >20 μM.
  2. ND: not determined; cTC50 is the concentration required to inhibit growth of Vero cell line by 50%. TC50 is the average of two independent experiments.