Effect of anti-RANKL antibody OYC1 on morphology of tibias in RA- and RA+ mice. Tibias excised from RA-/Ab-, RA-/Ab+, RA+/RA-, and RA+/Ab+ mice were subjected to three-dimensional micro-computed tomography. (A) Representative images of metaphysis of tibias. Bars: 600 μm. Trabecular bone volume (BV/TV) (B, C), trabecular thickness (Tb.Th) (D, E), trabecular number (Tb.N) (F, G), and trabecular space (Tb.Sp) (H, I) in the metaphysis of tibias from RA- (B, D, F, H) and RA+ (C, E, G, I) mice was quantified. Data are shown as the mean ± SD (n = 6). Mann-Whitney U-test was used for statistical analysis. Significant differences are indicated in their p-values. NS shows that the difference between the groups is not significant.