Double-cysteine-mutated Shaker channel. Oxaliplatin does not affect a double-cysteine-mutated Shaker (R362C/F416C) channel. A) Current family in control solution. Voltage steps between -80 and +30 mV in steps of 10 mV. Holding voltage = -80 mV. Time between each step is 2 s. B) Current family with 240 μM oxaliplatin added to the extracellular solution. C) Conductance versus voltage curve for the data from A and B. The experiments were carried out in Cl- -containing solutions with the two-electrode voltage clamp technique.