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Table 1 Observed PALB2 variants among the Finnish familial and unselected prostate cancer cases.

From: PALB2 variants in hereditary and unselected Finnish Prostate cancer cases

Exon/Intron Nt change Amino acid Change Carrier Frequency (OR; 95% CI)
    Familial Unselected Controls
PALB2      
Ex 4 1592delT Leu531>Fs>Stop 1/178 (0.6%) (4.3; 0.3-68.8) 2/748 (0.3%) (2.0; 0.2-22.2) 1/760 (0.2%)
Ex 4 1674A>G Gln559Agr 36/178 (20.2%) (1.2; 0.8-1.8) 153/748(20.5%) (1.2; 0.9-1.5) 134/760(18.0%)
Ex 8 2794G>A Val932 Met 4/178 (2.2%) (1.0; 0.3-3.4) 7/285(2.5%) (1.2; 0.4-3.1) 10/470 (2.1%)
Ex 9 2993G>A Gly998Glu 8/178 (4.5%) (1.6; 0.7-3.5) 35/748 (4.9%) (1.6; 0.9-2.8) 22/760 (2.9%)
Ex 12 3300T>G Thr1100Thr 6/178 (3.4%) (0.8; 0.3-2.0) 30/748 (3.9%) (1.0: 0.6-1.7) 30/760 (3.9%)
5'UTR G>A - 8/178 (4.5%) (1.8; 0.7-4.4) 14/285 (4.9%) (2.0; 0.9-4.3) 12/470 (2.6%)