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Table 2 Lipid Distribution of Sciatic Nerve in Hexb Micea

From: Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

Lipids

Hexb+/-

Hexb-/-

Total Gangliosides

44.2 ± 1.2

39.7 ± 3.8

 

(nb = 5)

(n = 5)

Individual Gangliosidesc (n = 2)

   GM3

2.0, 2.5

2.8, 1.9

   GM2

n.d.d

1.1, 1.0

   LM1

1.5, 3.5

1.4, 0.8

   GM1

0.7, 1.4

1.8, 1.0

   GD3

0.6,0.6

0.6, 0.8

   GD1a

23.1, 23.9

23.8, 19.0

   GT1a

0.3, 0.3

1.0, 0.4

   GD1b

1.4, 1.8

1.6, 1.5

   GT1b

8.7, 7.7

8.6, 7.0

   GQ1b

6.5, 5.1

5.1, 4.5

Neutral

   Triglycerides

38.2 ± 2.4

43.6 ± 5.0

   Cholesterol

9.9 ± 1.2

11.4 ± 1.5

   Cerebrosides

6.6 ± 0.5

6.7 ± 0.4

   Phosphatidylethanolamine

5.4 ± 0.4

6.0 ± 0.4

   Phosphatidylcholine

4.3 ± 0.3

3.8 ± 0.2

   Sphingomyelin

2.6 ± 0.3

2.4 ± 0.4

 

(n = 6)

(n = 6)

Acidic

   Sulfatides

1.4 ± 0.1

1.4 ± 0.1

   Phosphatidylserine

3.2 ± 0.3

3.1 ± 0.1

   Phosphatidylinositol

0.4 ± 0.0

0.4 ± 0.0

 

(n = 5)

(n = 6)

  1. a Values are expressed as mean ± SEM in mg/100 mg dry weight (neutral, acidic) or μg sialic acid/100 mg dry weight (ganglioside).
  2. b n, the number of independent samples analyzed. (6–8 sciatic nerves were pooled per independent sample)
  3. c due to small amounts of gangliosides present in tissue, only two samples were obtained for analysis
  4. d n.d., not detected