|
Lipids
|
Hexb+/-
|
Hexb-/-
|
|---|
|
Total Gangliosides
|
44.2 ± 1.2
|
39.7 ± 3.8
|
| |
(nb = 5)
|
(n = 5)
|
|
Individual Gangliosidesc (n = 2)
|
|
GM3
|
2.0, 2.5
|
2.8, 1.9
|
|
GM2
|
n.d.d
|
1.1, 1.0
|
|
LM1
|
1.5, 3.5
|
1.4, 0.8
|
|
GM1
|
0.7, 1.4
|
1.8, 1.0
|
|
GD3
|
0.6,0.6
|
0.6, 0.8
|
|
GD1a
|
23.1, 23.9
|
23.8, 19.0
|
|
GT1a
|
0.3, 0.3
|
1.0, 0.4
|
|
GD1b
|
1.4, 1.8
|
1.6, 1.5
|
|
GT1b
|
8.7, 7.7
|
8.6, 7.0
|
|
GQ1b
|
6.5, 5.1
|
5.1, 4.5
|
|
Neutral
|
|
Triglycerides
|
38.2 ± 2.4
|
43.6 ± 5.0
|
|
Cholesterol
|
9.9 ± 1.2
|
11.4 ± 1.5
|
|
Cerebrosides
|
6.6 ± 0.5
|
6.7 ± 0.4
|
|
Phosphatidylethanolamine
|
5.4 ± 0.4
|
6.0 ± 0.4
|
|
Phosphatidylcholine
|
4.3 ± 0.3
|
3.8 ± 0.2
|
|
Sphingomyelin
|
2.6 ± 0.3
|
2.4 ± 0.4
|
| |
(n = 6)
|
(n = 6)
|
|
Acidic
|
|
Sulfatides
|
1.4 ± 0.1
|
1.4 ± 0.1
|
|
Phosphatidylserine
|
3.2 ± 0.3
|
3.1 ± 0.1
|
|
Phosphatidylinositol
|
0.4 ± 0.0
|
0.4 ± 0.0
|
| |
(n = 5)
|
(n = 6)
|
- a Values are expressed as mean ± SEM in mg/100 mg dry weight (neutral, acidic) or μg sialic acid/100 mg dry weight (ganglioside).
- b n, the number of independent samples analyzed. (6–8 sciatic nerves were pooled per independent sample)
- c due to small amounts of gangliosides present in tissue, only two samples were obtained for analysis
- d n.d., not detected
