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Figure 2 | Journal of Negative Results in BioMedicine

Figure 2

From: Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

Figure 2

Diffraction from Optic and Sciatic Nerves in Hexb+/- and Hexb-/- Mice. (A) Representative examples of data for sciatic (left) and optic (right) nerves from Hexb+/- (black) and Hexb-/- (grey) mice. Whereas indistinguishable patterns were obtained for sciatic nerve samples from both groups, optic nerves from Hexb-/- mice showed weaker myelin scatter compared to those from Hexb+/- mice. The Bragg orders for the x-ray peaks are indicated as 1–5. (B) The fraction of total x-ray scatter (M+B) that is accounted for by compact myelin (M) (i.e., M/(M+B)), was plotted against the myelin period (d) [16]. For optic nerve myelin, the Hexb+/- () and Hexb-/- () mice have similar periods; however, the Hexb-/- mice have less relative myelin in the CNS when compared to the Hexb+/- mice (n = 3–4 per group, p < 0.05; two-tailed, unpaired t-test). For sciatic nerve, the Hexb+/- (□) and Hexb-/- (■) mice have similar periods and relative amounts of compact myelin (n = 8 per group). Thus, x-ray diffraction revealed no myelin abnormalities in the PNS and less relative amounts of compact myelin in the CNS of the Hexb-/- mice.

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