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Figure 2 | Journal of Negative Results in BioMedicine

Figure 2

From: Capsaicin- resistant arterial baroreceptors

Figure 2

Capsaicin-resistant baroreceptors. Capsaicin effects on the pressure-discharge relations of regularly discharging, single-fiber, aortic BRs were assessed by comparing four key discharge parameters. Pressure threshold (Pth) and threshold frequency (Fth) were calculated as the average pressure and frequency (respectively) for the first 10 discharge points. The slope sensitivity (Sth) was based on a least squares, linear regression fit of the discharge points over the initial 20–40 mmHg of the relation (white dashed line). The maximum discharge (Fmax) averaged the discharge frequency sampled from the highest 20 mmHg for that unit – generally >200 points. The classification as regularly discharging was based on a moderate (<%) coefficient of variation (COV) of discharge, high Fmax (>50 Hz) and high slope-sensitivity (>0.5 spikes/sec/mmHg) – all characteristic of A-fiber BRs. 1 μM CAP for 15 min failed to alter the pressure-discharge response of regularly discharging BRs (n = 10) or their mean discharge parameters. The COV was calculated using this same sample and for this BR was 2.94%. Linear regression fit (Y = A + B * X) yielded A=-75.0 ± 0.9, B = 0.95 ± 0.01, R = 0.99 ± 1.68, n = 470 points, p-value<0.0001. Averages (± SEM) of these derived parameters for Pth, Sth, Fth and Fmax.

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