Skip to main content
Figure 1 | Journal of Negative Results in BioMedicine

Figure 1

From: Searching for plasticity in dissociated cortical cultures on multi-electrode arrays

Figure 1

Reactions to pharmacological manipulations. A Adding 1 mM Mg2+ (to the baseline of 0.8 mM) stopped spontaneous bursts, and reduced the array-wide spike detection rate (ASDR) outside of bursts slightly. B Adding 1 or 3 mM K+ (to the baseline of 5.4 mM) increased burst rates and inter-burst firing rates. The fraction of spikes that occurred inside bursts (as opposed to between bursts) remained similar. C CNQX, an AMPA channel blocker, inhibited bursting and reduced baseline ASDR. D AP5, an NMDA channel blocker, inhibited bursting for a limited period of time. E Bicuculline methiodide (BMI), a GABA channel blocker, increased burstiness. (Data for A–E were obtained from different cultures, N = 1 for each substance. Baselines were recorded immediately prior to adding drugs. Since the results were fully consistent with expectations, a more in-depth investigation was deemed unnecessary.)

Back to article page