Table 1 Plasma levels of TNF alpha, ghrelin, leptin and adiponectin among healthy male volunteers during short-term intervention with either dexamethasone or placebo.
Circulating levels of metabolically active hormones | Pre-treatment | Post-treatment | Significance of the difference between changes (pre-post), Placebo vs. Dexamethasone (p-value) | ||
|---|---|---|---|---|---|
Placebo (n = 12) | Dexamethasone (n = 13) | Placebo (n = 12) | Dexamethasone (n = 13) | ||
Insulin sensitivity (HOMA-S)* | 7.55 (6.885–8.85) | 8.28 (7.26–9.85) | 7.07 (6.03–9.96) | 5.46 (4.79–7.39) | < 0.001 |
Insulin sensitivity index (ISI)* | 1.16 (0.81–1.58) | 1.35 (0.95–2.48) | 0.94 (0.53–2.46) | 0.38 (0.26–0.77) | < 0.001 |
Tumor Necrosis Factor alpha (pg/ml) | 660 (230–1580) | 600 (0–1080) | 620 (240– 1460) | 580 (0–1080) | 0.68 |
Ghrelin (pg/ml) | 422 (239–591) | 342 (285–497) | 359 (265–465) | 291 (188–347) | 0.19 |
Leptin (pg/ml) | 14,400 (8,400–25,600) | 10,700 (4,200–19,800) | 17,800 (2,700–22,600) | 15,900 (4,200–30,500) | 0.85 |
Adiponectin (ng/ml) | 460 (270–1380) | 810 (430–2020) | 490 (390–700) | 1420 (910–2120) | 0.17 |