Figure 1
Genotype frequencies of the microsatellite representing the TNFRSF17 gene. Only genotypes with a frequency of > 0.01 are included. Alleles of the respective microsatellite are indicated as numbers in the X-axis according to their length in bp. For example: 1–1 (read from the number below the numerical series and the first number of the numerical series) means homozygous genotype for microsatellite allele number one and 1–4 heterozygous genotype for allele 1 and 4. Genotypes comprising allele 2 are over-represented within the control group (47% vs. 29%; pc = 0.0042 with c = 2), whereas allele 3 genotypes are more frequent in the patient cohort (58% vs. 52% pc = 0.3130; c = 2). Therefore, allele 2 might imply a protective effect and/or allele 3 a predisposing effect on CD. Interestingly, the genotype 2–3 is more prevalent in the control group. This result can be interpreted by a different effect size of allele 2 (↑) as compared to allele 3, or the significant difference of this microsatellite is only due to linkage of allele 2 with a protective factor.