| Age at pathology (d) | |||||
---|---|---|---|---|---|---|
Genetic modification | Relative SOD1 protein levels (human/mouse) spinal cord | Total increase in SOD1 activity | ALS onset (d) | Motor neuron vacuolation | Motor neuron loss | Reactive astrogliosis |
Genomic hSOD1 G37R(42) [10] | 12.3 | 14.5 | 106-121 | 77 | 105 | 77 |
Genomic hSOD1 G37R(9) [10] | 6.2 | 9 | 152-183 | 70 | 105 | 35 |
Genomic hSOD1 G37R(106) [10] | 5.3 | 7.2 | 167-228 | 189 | 126 | 77 |
Genomic hSOD1 G37R(29) [10] | 5 | 7 | 183-243 | none | 133 | 77 |
Genomic hSOD1 wild-type (76) [10] | 10.5 | 9.2 | None by 548d | none | none | none |