Table 1 Effects of topoisomerase I and dual inhibitors on Trypanosoma cruzi after 72Â h of treatment
Drugs | Target | IC50(ÎĽM) | Ultrastructural effects |
|---|---|---|---|
Topotecan | Eukaryotic Topo I Inhibitor | 110 | Unpacking of nuclear heterochromatin and mitochondrial swelling |
Irinotecan | Eukaryotic Topo I Inhibitor | > 300 | No modifications |
Baicalein | Eukaryotic Dual Inhibitor | 62,83 | No modifications |
Luteolin | Eukaryotic Dual Inhibitor | > 300 | No modifications |
Evodiamine | Eukaryotic Dual Inhibitor | 90,73 | No modifications |