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Table 1 Overview of the reported baseline blood concentrations of CNP and NT-proCNP (mean ± SD)

From: Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation

Author, year Age n Subgroup CNP (pg/ml) NT-proCNP (pg/ml)
     Serum Plasma Serum Plasma
Del Ry, 2012 [11] 0-3d 41 newborns   11.6 ± 2.1*R   
4-30d 24 newborns   16.4 ± 3.7*R   
1-12 m 22 infants   15.4 ± 2.7*R   
1-12 32 childrens   13.6 ± 2.3*R   
64 ± 1 32 healthy adults   7.4 ± 1.0*R   
Del Ry, 2011 [10] 64 ± 1 130 heart failure   7.86 ± 0.41*R   67.1 ± 7.36
63 ± 2 19 diabetes   8.70 ± 1.62*R   51.5 ± 5.75
52 ± 1 24 liver cirrhosis   4.97 ± 0.55*R   78.4 ± 19.9
61 ± 2 73 healthy   2.35 ± 0.11*R   45.5 ± 1.84
Olewicz-Gawlik, 2010 [17] 60 ± 15 40 RA    105 ± 189  
30 healthy    50 ± 35  
Vlachopoulos, 2009 [21] 57 ± 10 52 erectile dysfunction     2.28 ± 0.87
matched 31 healthy     3.70 ± 0.76
Palmer, 2009 [19] 64 ± 9 120 cardiovascular disease   1.43*R,a   187.0a
Dietmann, 2008 [14] 0.8-3.6 50 Malaria, severe     120 ± 72
0.8-2.0 39 Malaria, uncomplicated healthy     125.0 ± 49
25
0.8-6.4
155 ± 70
Yagci, 2008 [22] 34 ± 6 26 healthy 800 ± 270E    
34 ± 9 28 Behcet, active 490 ± 120E    
25 Behcet, inactive 650 ± 200E    
Del Ry, 2007 [12] 62 ± 2 51 ILVD   7.0 ± 0.9*R   
61 ± 2 60 healthy   2.5 ± 0.12*R   
Olney, 2007 [18] 13 ± 2 10 GHD baseline     339 ± 40
GHD under therapy     622 ± 157
14 ± 1 11 healthy     432 ± 64
Lupattelli, 2006 [16] 35-60 44 Hyperlipidemia   4100 ± 5800*E   
matched 20 healthy controls   5700 ± 3300*E   
Del Ry, 2005 [13] 61 ± 2 21 healthy   2.7 ± 0.2*R   
Prickett, 2001 [20] 33 - 91 22 heart failure     105 ± 5.4
25 - 55 16 healthy     80 ± 3.2
Gülberg, 2000 [15] 57 ± 2 20 liver cirrhosis, RI   2.7 ± 0.4*R   
52 ± 2 20 liver cirrhosis, no RI   3.0 ± 0.2*R   
45 ± 6 11 healthy   4.2 ± 0.4*R   
present study 29 ± 2 12 healthy 997 ± 379E 991 ± 489*E 58.5 ± 28.3 60.3 ± 23.9
      1933 ± 699°E   
  1. At baseline, CNP concentrations are measured in blood samples anticoagulated either with EDTA(*) or sodium-citrate (°). Concentration of CNP was measured either with RIA-assay (R) or ELISA-assay (E). Unless otherwise indicated (d = days, m = months), age is given in years. a = arterial blood sample, CVRF = cardiovascular risk factors, RA = rheumatoid arthritis, ILVD = idiopathic left ventricle dysfunction, RI = renal insufficiency, GHD = growth hormone deficiency.