Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study

Table 2 Estimated glomerular filtration rate by green tea consumption status and ND2-237 Leu/Met genotype

Genotype and green tea consumption	eGFR (ml/min/1.73 m²)	eGFR^† (ml/min/1.73 m²)	eGFR^‡ (ml/min/1.73 m²)
ND2-237Leu (N = 239)
≤1 cup per day (N = 64)	81.7 ± 1.6	80.1 ± 1.6	78.5 ± 2.0
2–3 cups per day (N = 72)	80.2 ± 1.5	79.6 ± 1.5	77.2 ± 2.0
4–5 cups per day (N = 52)	75.6 ± 1.8	77.1 ± 1.7	74.4 ± 2.1
≥6 cups per day (N = 51)	77.8 ± 1.8	79.2 ± 1.7	76.6 ± 2.2
	P for trend = 0.031	P for trend = 0.484	P for trend = 0.262
ND2-237Met (N = 155)
≤1 cup per day (N = 43)	84.9 ± 1.9	84.1 ± 1.8	81.7 ± 2.4
2–3 cups per day (N = 52)	80.3 ± 1.7	79.6 ± 1.7	77.6 ± 2.3
4–5 cups per day (N = 31)	82.2 ± 2.2	82.5 ± 2.1	82.2 ± 2.6
≥6 cups per day (N = 29)	78.1 ± 2.3	80.4 ± 2.3	79.0 ± 2.8
	P for trend = 0.049	P for trend = 0.355	P for trend = 0.674

eGFR: estimated glomerular filtration rate. ^†eGFR is given as least-square mean ± S.E. adjusted for age, body mass index; ^‡eGFR is given as least-square mean ± S.E. adjusted for age, body mass index, habitual smoking, alcohol consumption, coffee consumption and antihypertensive medication use. Bonferroni correction for multiple comparisons was used.

ISSN: 1477-5751