Table 1 QUADAS results
| Â | Bigelow | Compton | Adler |
|---|---|---|---|
1. Was the spectrum of patients representative of the patients who will receive the test in practice? | No | No | No |
2. Were selection criteria clearly described? | No | No | No |
3. Is the reference standard likely to correctly classify the target condition? | No | No | No |
4. Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests? | Yes | Yes | Yes |
5. Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis? | Yes | No | No |
6. Did patients receive the same reference standard regardless of the index test result? | Yes | No | No |
7. Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)? | No | No | No |
8. Was the execution of the index test described in sufficient detail to permit replication of the test? | No | No | No |
9. Was the execution of the reference standard described in sufficient detail to permit its replication? | Yes | No | No |
10. Were the index test results interpreted without knowledge of the results of the reference standard? | No | No | No |
11. Were the reference standard results interpreted without knowledge of the results of the index test? | Yes | No | No |
12. Were the same clinical data available when test results were interpreted as would be available when the test is used in practice? | n/a | n/a | n/a |
13. Were uninterpretable/ intermediate test results reported? | No | No | No |
14. Were withdrawals from the study explained? | No | No | No |